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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of different extracts of L. alba in tail immersion test

From: In vivo and in silico evaluation of analgesic activity of Lippia alba

Treatment groupDosenLatency Time (s)
0 min+  30 min+ 60 min+ 90 min
Control10 ml/kg52.39 ± 0.213.85 ± 0.053.53 ± 0.103.02 ± 0.14
Morphin5 mg/kg54.59 ± 0.29*11.31 ± 0.19*11.55 ± 0.21*11.26 ± 0.37*
ME250 mg/kg53.68 ± 0.29*2.92 ± 0.422.94 ± 0.20*3.43 ± 0.15
ME500 mg/kg54.25 ± 0.07*4.53 ± 0.124.68 ± 0.15*3.15 ± 0.15
PEE250 mg/kg53.11 ± 0.123.14 ± 0.334.46 ± 0.18*3.02 ± 0.14
PEE500 mg/kg54.08 ± 0.323.87 ± 0.425.65 ± 0.25*5.25 ± 0.79*
DCME250 mg/kg53.63 ± 0.33*3.57 ± 0.363.35 ± 0.133.39 ± 0.18
DCME500 mg/kg54.29 ± 0.23*3.96 ± 0.254.80 ± 0.32*3.39 ± 0.79
  1. Latency time values are present as mean ± standard error of mean. 0 min means 30 min before drug administration, + 30 min, + 60 min and + 90 min indicate 30, 60 and 90 min after the administration of drug and extract, respectively. Tests of within-subjects effects reveal that for the factor ‘Time’ calculated F = 13.55 for all methods and P value = 0.000 in every case. So time is highly significant at any level of significance. *P < 0.05, vs control. Repeated measure analysis of variance with Dunnett’s multiple comparison was performed to analyze this data set. ME: methanolic extract; PEE: petroleum ether extract; DCME: dichloromethane extract