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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of different extracts of L. alba in tail immersion test

From: In vivo and in silico evaluation of analgesic activity of Lippia alba

Treatment group

Dose

n

Latency Time (s)

0 min

+  30 min

+ 60 min

+ 90 min

Control

10 ml/kg

5

2.39 ± 0.21

3.85 ± 0.05

3.53 ± 0.10

3.02 ± 0.14

Morphin

5 mg/kg

5

4.59 ± 0.29*

11.31 ± 0.19*

11.55 ± 0.21*

11.26 ± 0.37*

ME

250 mg/kg

5

3.68 ± 0.29*

2.92 ± 0.42

2.94 ± 0.20*

3.43 ± 0.15

ME

500 mg/kg

5

4.25 ± 0.07*

4.53 ± 0.12

4.68 ± 0.15*

3.15 ± 0.15

PEE

250 mg/kg

5

3.11 ± 0.12

3.14 ± 0.33

4.46 ± 0.18*

3.02 ± 0.14

PEE

500 mg/kg

5

4.08 ± 0.32

3.87 ± 0.42

5.65 ± 0.25*

5.25 ± 0.79*

DCME

250 mg/kg

5

3.63 ± 0.33*

3.57 ± 0.36

3.35 ± 0.13

3.39 ± 0.18

DCME

500 mg/kg

5

4.29 ± 0.23*

3.96 ± 0.25

4.80 ± 0.32*

3.39 ± 0.79

  1. Latency time values are present as mean ± standard error of mean. 0 min means 30 min before drug administration, + 30 min, + 60 min and + 90 min indicate 30, 60 and 90 min after the administration of drug and extract, respectively. Tests of within-subjects effects reveal that for the factor ‘Time’ calculated F = 13.55 for all methods and P value = 0.000 in every case. So time is highly significant at any level of significance. *P < 0.05, vs control. Repeated measure analysis of variance with Dunnett’s multiple comparison was performed to analyze this data set. ME: methanolic extract; PEE: petroleum ether extract; DCME: dichloromethane extract