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International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of different extracts of L. alba in hot plate test

From: In vivo and in silico evaluation of analgesic activity of Lippia alba

Treatment groupDosenLatency Time (s)
0 min+  30 min+ 60 min+ 90 min
Control10 ml/kg56.67 ± 0.086.90 ± 0.389.77 ± 0.409.18 ± 0.16
Morphine5 mg/kg58.52 ± 0.08*10.50 ± 0.42*11.99 ± 0.31*13.96 ± 0.10*
ME250 mg/kg56.35 ± 0.148.36 ± 0.3110.58 ± 0.9812.09 ± 0.26*
ME500 mg/kg56.91 ± 0.109.36 ± 0.38*10.49 ± 0.5613.13 ± 0.53*
PEE250 mg/kg56.90 ± 0.108.29 ± 0.4910.42 ± 0.3810.94 ± 0.58*
PEE500 mg/kg57.20 ± 0.149.31 ± 0.19*11.86 ± 0.26*13.25 ± 0.45*
DCME250 mg/kg55.53 ± 0.347.71 ± 0.4210.77 ± 0.2913.16 ± 0.51*
DCME500 mg/kg55.84 ± 0.509.41 ± 0.20*12.00 ± 0.17*13.48 ± 0.33*
  1. Latency time values are present as mean ± standard error of mean. 0 min means 30 min before drug administration, + 30 min, + 60 min and + 90 min indicate 30, 60 and 90 min after drug and extract administration, respectively. Tests of within-subjects effects reveal that for the factor ‘Time’ calculated F = 38.472 for all methods and P value = 0.000 in every case. So time is highly significant at any level of significance. *P < 0.05, vs control. Repeated measure analysis of variance with Dunnett’s multiple comparison was performed to analyze this data set. ME: methanolic extract; PEE: petroleum ether extract; DCME: dichloromethane extract