Anti-proliferative and immunomodulatory activities of fractions from methanol root extract of Abrus precatorius L

Okoro, Emeka E.; Osoniyi, Omolaja R.; Jabeen, Almas; Shams, Sidrah; Choudhary, M. I.; Onajobi, Funmilayo D.

doi:10.1186/s40816-019-0143-x

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Identified compounds from methanolic crude extract of A. precatorius roots

From: Anti-proliferative and immunomodulatory activities of fractions from methanol root extract of Abrus precatorius L

Peak #	Compound	Formula	t_R (min)	Area %	Remarks
1	Benzoic acid	C₇H₆O₂	7.88	0.07	antimicrobial, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory
2	1-Dodecanol	C₁₂H₂₆O	15.23	0.38	An insect attractant, pesticide
3	Benzaldehyde, 4-hydroxy-3,5-dimethoxy-	C₉H₁₀O₄	19.65	0.08	Antioxidant, antimicrobial and hypoglycemic
4	1-Hexadecanol	C₁₆H₃₄O	19.88	0.21	Emulsifier
5	Ethanol, 2-(dodecyloxy)-	C₁₄H₃₀O₂	20.76	0.13
6	1H-Indole-3-ethanol	C₁₀H₁₁NO	21.83	0.46	Estradiol metabolism
7	Hexadecanoic acid, methyl ester	C₁₇H₃₄O₂	26.83	5.31	Antioxidant, anti-inflammatory
8	Dibutyl phthalate	C₁₆H₂₂O₄	28.32	0.54	Antibacterial
9	n-Hexadecanoic acid	C₁₆H₃₂O₂	28.58	0.75	Antibacterial, antifungal
10	Heptadecanoic acid, methyl ester	C₁₈H₃₆O₂	31.51	0.36	Antimicrobial
11	9,12-Octadecadienoic acid (Z,Z)-, methyl ester	C₁₉H₃₄O₂	35.99	7.28	Antibacterial
12	11-Octadecenoic acid, methyl ester	C₁₉H₃₆O₂	36.44	5.08	Antimicrobial
14	Octadecanoic acid, methyl ester	C₁₉H₃₈O₂	37.89	1.27	Antimicrobial, anti-inflammatory, anticancer
15	9,12-Octadecadienoic acid (Z,Z)-	C₁₈H₃₂O₂	38.22	0.46	Antibacterial
16	cis-Vaccenic acid	C₁₈H₃₄O₂	38.54	0.63	Antibacterial, hypolipidemic
17	Benzene, 1,1′-tetradecylidenebis-	C₂₆H₃₈	43.96	1.11	Antimicrobial
18	5-Methoxy-3,7-dihydroxyflavanone	C₁₆H₁₄O₅	47.19	2.66	Antioxidant, anti-inflammatory, anticancer
19	1,2-Benzenedicarboxylic acid, diisooctyl ester	C₂₄H₃₈O₄	47.29	1.71	Antimicrobial, antioxidant, anticancer
20	3-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one	C₁₆H₁₂O₅	49.87	7.48	Anticancer, antihypertensive, antioxidant
21	13-Docosenamide, (Z)-	C₂₂H₄₃NO	50.15	0.94	Antimicrobial
22	2,2,4-Trimethyl-3-(3,8,12,16-tetramethyl-heptadeca-3,7,11,15-tetraenyl)-cyclohexanol	C₃₀H₅₂O	51.09	0.51
23	Benzaldehyde, 4-hydroxy-3,5-dimethoxy-, [(4-hydroxy-3,5-dimethoxyphenyl)methylene]hydrazone	C₁₈H₂₀N₂O₆	51.88	1.65	Indicator for laccase and peroxidase activity
24	4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6,8-dimethoxy-	C₁₉H₁₈O₉	52.69	2.93	antibacterial
25	6,6,7-Trimethyl-9-oxo-3-oxabicyclo(3.3.1) nonane 2,4-dinitrophenylhydrazone	C₁₇H₂₂N₄O₅	53.59	9.16
26	1,1′-Biphenyl-5-carboxylic acid, 2,3,4,4′-tetramethoxy-6′-methoxycarbon	C₁₉H₂₀O₈	53.76	1.13	Antibacterial
27	Silane, dimethyl(3-ethylphenoxy)tetradecyloxy-	C₂₄H₄₄O₂Si	54.71	41.09	Antimicrobial
28	Anthiaergosta-1,5,7,9-tetraene	C₂₈H₄₂	55.77	2.47
29	Cyclohexan-1-one-3α,5β-diacetic acid, 2α-(5-hydroxy-2,4-dimethoxyphenyl)-, diethyl ester	C₂₂H₃₀O₈	56.14	0.83	Antibacterial
30	α-Amyrin	C₃₀H₅₀O	56.64	0.47	Antimicrobial, antifungal, anti-inflammatory, anticancer
31	Lupeol	C₃₀H₅₀O	57.31	0.89	Antiprotozoal, anti-inflammatory, antitumor
32	Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecyl ester	C₃₅H₆₂O₃	60.73	1.07	Antifungal. antimicrobial

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