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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Immunomodulatory activities of methanolic crude extract and fractions A. precatorius roots

From: Anti-proliferative and immunomodulatory activities of fractions from methanol root extract of Abrus precatorius L

Fraction/Drug

WB ROS

PMNs ROS

NO

TNF-α

IC50 ± SD

IC50 ± SD

IC50 ± SD

IC50 ± SD

Crude

< 10.0

NT

NT

NT

Hexane

30.5 ± 0.3

0.6 ± 0.003

< 1

< 1

Ethyl acetate

< 10

0.6 ± 0.002

< 1

< 1

Butanol

21.0 ± 0.5

6.1 ± 0.8

NT

5.74 ± 0.05

Aqueous

12.0 ± 1.0

> 250

NT

NT

Standard (Ibuprofen)

11.2 ± 1.9

  1. NT: Not tested
  2. Values are presented as mean ± SD of triplicates at p < 0.001 by Student’s t test analysis. WB Whole Blood, NO Nitric Oxide, TNF Tumor necrosis factor, ROS Reactive Oxygen Species, PMNs Polymorphonuclear cells
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