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International Journal of Phytomedicine and Phytotherapy

Table 5 Effects of ethanol fruit extract of H. madagascariensis on biochemical parameters in Wistar rats (Mean ± S.E.M). The extract produced no statistically significant (P > 0.05) difference in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphate (ALP) in the extract treated groups when compared to the control. Meanwhile, there was a statistically significant (P < 0.01) difference in the creatinine level of the 500 mg/kg extract treated group and the control. There was no statistically significant (P > 0.05) difference in the level of blood urea and total cholesterol between the treated groups and the control. However, there was a marginal increase which is not statistically significant (P > 0.05) in the total protein level of the group administered with 1000 mg/kg of extract and the control

From: Toxicological implications of the fruit of Harungana madagascariensis on wistar rats

Parameters Extract (250 mg/kg) Extract (500 mg/kg) Extract (1000 mg/kg) Control (5 ml/kg)
AST (IU/L) 184.20 ± 10.41 184.60 ± 20.87 193.80 ± 9.50 170.40 ± 10.40
ALT (IU/L) 76.80 ± 4.90 72.40 ± 12.51 59.60 ± 10.21 66.20 ± 4.90
ALP (IU/L) 82.60 ± 11.46 72.20 ± 7.33 90.40 ± 14.90 73.00 ± 8.52
Urea (mmol/L) 7.02 ± 0.57 7.10 ± 0.58 6.86 ± 0.43 6.12 ± 0.31
Creatinine (μmol/L) 69.40 ± 5.95 76.00 ± 6.96* 65.00 ± 2.74 61.00 ± 1.87
TC (mmol/L) 2.50 ± 0.05 2.32 ± 0.12 2.44 ± 0.08 2.36 ± 0.68
Total protein (g/L) 55.40 ± 3.40 54.40 ± 0.93 60.00 ± 0.84 54.80 ± 2.13
  1. *P < 0.1, P > 0.05 Values were not statistically significant (P > 0.05) as compared to control. n = 5, T-test, P < 0.05