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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of MEHSR on cell growth inhibition, survival time and body weight gain of Ehrlich ascites carcinoma (EAC) cell bearing mice

From: Antioxidant and antineoplastic activities of roots of Hibiscus sabdariffa Linn. Against Ehrlich ascites carcinoma cells

Treatment

Viable EAC cells on day 6 after inoculation (×  107 cells/ml)

Percentage (%) cell growth inhibition

MST

(in days)

%ILS

Body weight gain (g) after 15 days

EAC + Control

3.64 ± 0.33

–

20.25 ± 1.70

–

16.00 ± 1.41

EAC + MEHSR (5 mg/kg)

2.01 ± 0.06*

44.42 ± 3.07

23.75 ± 1.25*

17.37 ± 3.41

8.75 ± 1.50*

EAC + MEHSR (10 mg/kg)

1.37 ± 0.14*

62.24 ± 2.71

28.00 ± 0.81*

38.97 ± 4.94

6.75 ± 0.95*

EAC + Bleomycin (0.3 mg/kg)

0.39 ± 0.09*

90.29 ± 1.14

39.25 ± .79*

93.82 ± 1.25

3.60 ± 0.45*

  1. Data are expressed as mean ± SD for six animals in each group. P < 0.05: against EAC control group. MST Mean survival time; % ILS Percentage increase of life span
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