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International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of Lophira lanceolata leaf extract on biomarkers of hepatic injuries in rats administered cisplatin

From: Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

Treatment groups

Serum biomarkers of hepatic injuries

T-Protein (g/dL)

Albumin (g/dL)

ALT (U/L)

AST (U/L)

ALP (U/L)

T-Bilirubin (mg/dL)

I. Normal control

6.68 ± 0.69

3.00 ± 0.13

30.12 ± 3.46

27.56 ± 5.17

22.32 ± 6.59

0.62 ± 0.12

II. 5 mg/kg Cisplatin

6.42 ± 0.70

3.50 ± 0.32

178.0 ± 38.5a

73.44 ± 2.75a

48.04 ± 3.09a

3.78 ± 1.15a

III. 200 mg/kg LLE

6.48 ± 0.41

3.12 ± 0.26

33.72 ± 5.98b

37.14 ± 9.58b

35.32 ± 5.87

0.56 ± 0.09b

IV. 400 mg/kg LLE

5.56 ± 0.37

2.98 ± 0.16

31.50 ± 2.83b

30.22 ± 3.26b

39.36 ± 10.1

0.48 ± 0.17b

V. 200 mg/kg LLE + CIS

7.28 ± 0.88

3.12 ± 0.16

44.08 ± 8.18b

42.56 ± 4.49b

34.60 ± 6.28

0.40 ± 0.14b

VI. 400 mg/kg LLE + CIS

6.24 ± 0.42

2.90 ± 0.20

66.40 ± 6.65b

34.16 ± 2.82b

34.40 ± 5.36

1.86 ± 0.10b

  1. Values are Mean ± SEM, n = 5; LLE - Lophira lanceolata leaf extract, CIS - Cisplatin
  2. asignificantly different from normal control (p < 0.05)
  3. bsignificantly different from cisplatin control (p < 0.05)