Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of Lophira lanceolata leaf extract on lipid profile and biomarkers of renal injuries in rats administered cisplatin

Treatment groups	Serum lipid profile and biomarkers of renal injuries
Treatment groups	Total Chol. (mg/dL)	TRG (mg/dL)	HDL-Chol. (mg/dL)	LDL-Chol. (mg/dL)	Urea (mg/dL)	Creatinine (mg/dL)
I. Normal control	116.6 ± 3.1	129.2 ± 5.1	36.82 ± 3.09	46.84 ± 3.15	27.46 ± 4.68	0.44 ± 0.17
II. 5 mg/kg Cisplatin	194.8 ± 24.0^a	149.5 ± 2.9^a	36.68 ± 3.20	133.5 ± 17.4^a	65.14 ± 6.96^a	1.92 ± 0.39^a
III. 200 mg/kg LLE	127.2 ± 11.9^b	117.7 ± 4.2^b	37.00 ± 3.84	58.78 ± 8.20^b	32.34 ± 3.71^b	1.06 ± 0.24^b
IV. 400 mg/kg LLE	94.2 ± 8.01^b	136.1 ± 1.9	40.40 ± 1.30	56.22 ± 6.10^b	33.08 ± 4.33^b	0.48 ± 0.07^b
V. CIS + 200 mg/kg LLE	109.3 ± 5.12^b	146.6 ± 14.6	41.44 ± 2.24	31.72 ± 5.48^b	30.28 ± 1.10^b	0.46 ± 0.09^b
VI. CIS + 400 mg/kg LLE	129.8 ± 0.82^b	128.8 ± 1.9^b	35.54 ± 4.73	80.92 ± 5.27^ab	38.08 ± 5.67^b	0.42 ± 0.19^b

Values are Mean ± SEM, n = 5; LLE - Lophira lanceolata leaf extract, CIS - Cisplatin
^asignificantly different from normal control (p < 0.05)
^bsignificantly different from cisplatin control (p < 0.05)