Groups | Liver function test |
---|
 | ALT (U/l) | ALP(U/l) | AST(U/l) | Bilirubin (mg/dl) |
---|
Group I | 51.95 ± 2.4 | 35.50 ± 3.1 | 105.50 ± 3.9 | 0.49 ± 0.04 |
Group II | 79.50 ± 3.7a** | 87.70 ± 4.1a** | 226.45 ± 6.9a** | 1.39 ± 0.07a** |
Group III | 73.15 ± 3.0bη | 80.45 ± 4.3bη | 195.08 ± 5.4b* | 1.28 ± 0.06bη |
Group IV | 60.55 ± 3.9b* | 70.55 ± 4.1b* | 135.15 ± 6.6b** | 0.75 ± 0.03b** |
Group V | 55.40 ± 3.3b* | 54.80 ± 3.1b** | 96.45 ± 4.1b** | 0.63 ± 0.04b** |
Group VI | 49.25 ± 3.7b** | 39.35 ± 3.8b** | 71.19 ± 3.4b** | 0.57 ± 0.02b** |
- All values were expressed as mean ± S.E.M (n = 3). (*) indicates statistically significant difference from the respective group (**p < 0.01) whereas (η) indicates statistically no significant difference from the respective group (p > 0.05) using ANOVA, followed by Dunnett’s multiple comparison test. a = while compared with healthy control, b = while compared with diabetic control. Group I = Healthy control, Group II = Diabetic control, Group III = Diabetic control + 10 mg/kg of gliclazide, Group IV = Diabetic control + 100 mg/kg CRME, Group V = Diabetic control + 200 mg/kg CRME, Group VI = Diabetic control + 400 mg/kg CRME