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International Journal of Phytomedicine and Phytotherapy

Table 5 Effect of L. pinnatifidum on carrageenan-induced paw edema in rats

From: Evaluation of antioxidant and anti-inflammatory potency of Lepidium pinnatifidum Ledeb

Treatment

Edema formation to %inhibition

1 h

2 h

3 h

4 h

Dic. Pot. (10 mg/kg)

0.777 ± 0.033

23.702 ± 3.291fghi

0.594 ± 0.064

24.910 ± 8.118e

0.481 ± 0.044

45.819 ± 4.966de

0.12 ± 0.027

81.081 ± 4.269a

LPM (400 mg/kg)

0.671 ± 0.047

34.018 ± 4.654bcd

0.455 ± 0.043

42.419 ± 5.500bc

0.38 ± 0.050

57.234 ± 5.664bc

0.175 ± 0.015

72.297 ± 2.385abc

LPM (200 mg/kg)

0.68 ± 0.033

33.240 ± 3.305cde

0.484 ± 0.022

38.808 ± 2.811cd

0.464 ± 0.035

47.749 ± 3.997de

0.267 ± 0.021

57.882 ± 3.370def

LPH (400 mg/kg)

0.563 ± 0.048

44.642 ± 4.712a

0.355 ± 0.030

55.108 ± 3.837a

0.245 ± 0.027

72.395 ± 3.140a

0.125 ± 0.067

80.247 ± 10.629a

LPH (200 mg/kg)

0.595 ± 0.011

41.514 ± 1.113ab

0.422 ± 0.013

46.570 ± 1.743abc

0.375 ± 0.013

57.717 ± 1.572bc

0.197 ± 0.024

68.918 ± 3.831bc

LPC (400 mg/kg)

0.705 ± 0.027

30.715 ± 2.709def

0.48 ± 0.02

39.350 ± 2.527cd

0.418 ± 0.032

52.893 ± 3.642cd

0.2 ± 0.032

68.468 ± 5.149bc

LPC (200 mg/kg)

0.751 ± 0.033

26.227 ± 3.325efg

0.541 ± 0.027

31.588 ± 3.531de

0.522 ± 0.043

41.157 ± 4.893ef

0.3 ± 0.020

52.702 ± 3.281ef

LPE (400 mg/kg)

0.598 ± 0.031

41.234 ± 3.074ab

0.392 ± 0.019

50.361 ± 2.496ab

0.317 ± 0.053

64.308 ± 6.050ab

0.15 ± 0.043

76.351 ± 6.811ab

LPE (200 mg/kg)

0.628 ± 0.060

38.289 ± 5.929abc

0.461 ± 0.044

41.696 ± 5.623bc

0.434 ± 0.038

51.125 ± 4.351cd

0.23 ± 0.036

63.738 ± 5.756cd

LPB (400 mg/kg)

0.761 ± 0.040

25.245 ± 3.985fgh

0.494 ± 0.042

37.545 ± 5.353cd

0.474 ± 0.036

46.623 ± 4.102de

0.237 ± 0.029

62.612 ± 4.615cde

LPB (200 mg/kg)

0.788 ± 0.035

22.580 ± 3.513ghi

0.574 ± 0.034

27.436 ± 4.368e

0.558 ± 0.027

37.138 ± 3.077fg

0.33 ± 0.021

47.972 ± 3.405fg

LPA

(400 mg/kg)

0.801 ± 0.046

21.318 ± 4.584 hi

0.541 ± 0.022

31.588 ± 2.865de

0.531 ± 0.026

40.192 ± 3.007ef

0.27 ± 0.020

57.432 ± 3.281def

LPA (200 mg/kg)

0.852 ± 0.031

16.269 ± 3.089i

0.612 ± 0.036

22.563 ± 4.597e

0.61 ± 0.037

31.350 ± 4.210g

0.368 ± 0.030

41.891 ± 4.853g

  1. Data values shown represent Mean ± SD and percentage inhibition at different concentrations; (n = 7). Different superscript (a-i) indicate significance at P < 0.05. LPM: L. pinnatifidum Methanol fraction. LPH: L. pinnatifidum n-Hexane fraction. LPC: L. pinnatifidum Chloroform fraction. LPE: L. pinnatifidum Ethyl acetate fraction. LPB: L. pinnatifidum Butanol fraction. LPA: L. pinnatifidum Aqueous fraction