Comparative study of the effects of Cassia spectabilis and Newbouldia laevis leaf extracts on diclofenac-induced hepatorenal oxidative damage in rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of CSE and NLE on liver and kidney antioxidant enzymes activities in DF-exposed rats

Treatment groups	Levels of liver and kidney antioxidant enzymes in rats
Treatment groups	Catalase (μmol/min/mg p)	SOD (μmol/min/mg p)	GPx (μmol/min/mg p)	GST (μmol/min/mg p)
Liver
I. Normal saline	12.55 ± 0.03	14.27 ± 0.15	11.04 ± 0.05	43.07 ± 0.11
II. DF + Saline	3.72 ± 0.09^a	4.42 ± 0.02^a	1.81 ± 0.03^a	18.11 ± 0.11^a
III. CSE + DF	10.91 ± 0.01^b	11.99 ± 0.06^b	7.87 ± 0.02^b	35.25 ± 0.41^b
IV. NLE + DF	9.38 ± 0.02^b	5.28 ± 0.02^b	3.86 ± 0.02^b	21.36 ± 0.21^b
Kidney
I. Normal saline	3.12 ± 0.01	11.24 ± 0.13	9.46 ± 0.05	16.91 ± 0.25
II. DF + Saline	0.89 ± 0.02^a	3.16 ± 0.03^a	1.28 ± 0.05^a	4.13 ± 0.09^a
III. CSE + DF	2.81 ± 0.05^b	9.52 ± 0.12^b	7.21 ± 0.05^b	14.66 ± 0.14^b
IV. NLE + DF	1.19 ± 0.02^b	4.25 ± 0.02^b	3.79 ± 0.01^b	8.03 ± 0.03^b

Values are Mean ± SEM, n = 6; P Protein, DF Diclofenac sodium, ^asignificantly different from normal control (p < 0.01), ^bsignificantly different from DF control (p < 0.01)