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International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of CSE and NLE on serum markers of hepatorenal oxidative damage in DF-exposed rats

From: Comparative study of the effects of Cassia spectabilis and Newbouldia laevis leaf extracts on diclofenac-induced hepatorenal oxidative damage in rats

Biochemical parameters Treatment groups
I. Normal control II. 10 mg/kg DF + Saline III. 250 mg/kg CSE + DF IV. 250 mg/kg NLE + DF
ALT (U/L) 8.92 ± 0.05 80.94 ± 0.74a 15.72 ± 0.18b 27.2 ± 0.40b
AST (U/L) 14.06 ± 0.05 124.91 ± 0.53a 20.66 ± 0.19b 36.6 ± 0.20b
GGT (U/L) 39.97 ± 0.10 125.39 ± 0.22a 47.73 ± 0.18b 66.7 ± 0.16b
G6Pase (U/L) 33.35 ± 0.46 14.07 ± 0.10a 27.06 ± 0.28b 18.0 ± 0.18b
Protein (g/dl)×10−2 16.0 ± 0.78 7.0 ± 0.44a 13.0 ± 2.35b 10.0 ± 0.29b
Albumin (g/dl)×10−2 4.0 ± 0.24 2.0 ± 0.34a 4.0 ± 0.26b 3.0 ± 0.18b
Globulin (g/dl)×10−2 12.0 ± 0.91 5.0 ± 0.19a 9.0 ± 2.35b 7.0 ± 0.29b
BUN (mmol/L) 5.03 ± 0.04 34.23 ± 0.81a 6.47 ± 0.10b 20.8 ± 0.24b
Creatinine (μmol/L) 100.6 ± 0.43 481.2 ± 5.64a 123.6 ± 0.23b 341.1 ± 0.32b
MDA (nmol/mg p) 2.96 ± 0.03 12.51 ± 0.22a 4.66 ± 0.05b 8.01 ± 0.08b
GSH (μg/ml) 60.49 ± 0.53 30.67 ± 0.27a 48.15 ± 0.27b 36.3 ± 0.21b
SOD (U/mg p) 11.29 ± 0.11 3.60 ± 0.07a 8.99 ± 0.08b 6.10 ± 0.02b
CAT (U/mg p) 8.99 ± 0.08 2.02 ± 0.05a 6.10 ± 0.03b 6.17 ± 0.03b
GPx (U/mg p) 9.13 ± 0.25 2.39 ± 0.02a 6.24 ± 0.04b 4.46 ± 0.25b
GST (U/mg p) 41.05 ± 0.59 15.17 ± 0.19a 31.99 ± 0.68b 19.14 ± 0.24b
  1. Values are Mean ± SEM, n = 6; DF Diclofenac sodium, asignificantly different from normal control (p < 0.01), bsignificantly different from diclofenac control (p < 0.01)