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International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of CSE and NLE on serum markers of hepatorenal oxidative damage in DF-exposed rats

From: Comparative study of the effects of Cassia spectabilis and Newbouldia laevis leaf extracts on diclofenac-induced hepatorenal oxidative damage in rats

Biochemical parameters

Treatment groups

I. Normal control

II. 10 mg/kg DF + Saline

III. 250 mg/kg CSE + DF

IV. 250 mg/kg NLE + DF

ALT (U/L)

8.92 ± 0.05

80.94 ± 0.74a

15.72 ± 0.18b

27.2 ± 0.40b

AST (U/L)

14.06 ± 0.05

124.91 ± 0.53a

20.66 ± 0.19b

36.6 ± 0.20b

GGT (U/L)

39.97 ± 0.10

125.39 ± 0.22a

47.73 ± 0.18b

66.7 ± 0.16b

G6Pase (U/L)

33.35 ± 0.46

14.07 ± 0.10a

27.06 ± 0.28b

18.0 ± 0.18b

Protein (g/dl)×10−2

16.0 ± 0.78

7.0 ± 0.44a

13.0 ± 2.35b

10.0 ± 0.29b

Albumin (g/dl)×10−2

4.0 ± 0.24

2.0 ± 0.34a

4.0 ± 0.26b

3.0 ± 0.18b

Globulin (g/dl)×10−2

12.0 ± 0.91

5.0 ± 0.19a

9.0 ± 2.35b

7.0 ± 0.29b

BUN (mmol/L)

5.03 ± 0.04

34.23 ± 0.81a

6.47 ± 0.10b

20.8 ± 0.24b

Creatinine (μmol/L)

100.6 ± 0.43

481.2 ± 5.64a

123.6 ± 0.23b

341.1 ± 0.32b

MDA (nmol/mg p)

2.96 ± 0.03

12.51 ± 0.22a

4.66 ± 0.05b

8.01 ± 0.08b

GSH (μg/ml)

60.49 ± 0.53

30.67 ± 0.27a

48.15 ± 0.27b

36.3 ± 0.21b

SOD (U/mg p)

11.29 ± 0.11

3.60 ± 0.07a

8.99 ± 0.08b

6.10 ± 0.02b

CAT (U/mg p)

8.99 ± 0.08

2.02 ± 0.05a

6.10 ± 0.03b

6.17 ± 0.03b

GPx (U/mg p)

9.13 ± 0.25

2.39 ± 0.02a

6.24 ± 0.04b

4.46 ± 0.25b

GST (U/mg p)

41.05 ± 0.59

15.17 ± 0.19a

31.99 ± 0.68b

19.14 ± 0.24b

  1. Values are Mean ± SEM, n = 6; DF Diclofenac sodium, asignificantly different from normal control (p < 0.01), bsignificantly different from diclofenac control (p < 0.01)