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Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 The sedative effect of MESC on hole cross test in mice

From: Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice

Treatment

Dose (mg/kg)

 

Number of holes crossed

 

0 min.

30 mins.

60 mins.

90 mins.

120 mins.

Control

0.1 ml/mouse

21.60 ± 0.52

21.00 ± 0.84

18.60 ± 0.24

18.20 ± 0.73

17.40 ± 0.51

Diazepam

1

18.40 ± 0.51

9.80 ± 0.58*

5.20 ± 0.58*

3.00 ± 0.31*

2.00 ± 0.31*

MESC

200

21.60 ± 0.10

16.40 ± 0.51*

12.80 ± 0.37*

11.20 ± 0.37*

8.00 ± 0.31*

MESC

400

21.80 ± 2.34

14.80 ± 1.24*

10.20 ± 1.98*

6.00 ± 2.67*

4.20 ± 2.96*

MESC

600

22.20 ± 1.06

16.00 ± 0.70*

9.60 ± 0.24*

5.20 ± 0.20*

3.20 ± 0.20*

  1. i. * p < 0.001 vs control group
  2. ii.** p < 0.0001 vs control group.
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