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International Journal of Phytomedicine and Phytotherapy

Table 3 The sedative effect of MESC on hole cross test in mice

From: Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice

Treatment Dose (mg/kg)   Number of holes crossed  
0 min. 30 mins. 60 mins. 90 mins. 120 mins.
Control 0.1 ml/mouse 21.60 ± 0.52 21.00 ± 0.84 18.60 ± 0.24 18.20 ± 0.73 17.40 ± 0.51
Diazepam 1 18.40 ± 0.51 9.80 ± 0.58* 5.20 ± 0.58* 3.00 ± 0.31* 2.00 ± 0.31*
MESC 200 21.60 ± 0.10 16.40 ± 0.51* 12.80 ± 0.37* 11.20 ± 0.37* 8.00 ± 0.31*
MESC 400 21.80 ± 2.34 14.80 ± 1.24* 10.20 ± 1.98* 6.00 ± 2.67* 4.20 ± 2.96*
MESC 600 22.20 ± 1.06 16.00 ± 0.70* 9.60 ± 0.24* 5.20 ± 0.20* 3.20 ± 0.20*
  1. i. * p < 0.001 vs control group
  2. ii.** p < 0.0001 vs control group.