International Journal of Phytomedicine and Phytotherapy
Table 5 The anxiolytic effect of MESC on light-dark box test in mice
Treatment | Dose (mg/kg) | Latency time (s) | Transitions | Time spent in the light box (s) | Time spent in the dark Box (s) |
|---|---|---|---|---|---|
Control | 0.1 ml/mouse | 12.20 ± 0.37 | 19.40 ± 0.50 | 123.80 ± 0.73 (41.27) | 176.20 ± 0.73 (58.73) |
Diazepam | 1 | 26.40 ± 0.51* | 8.80 ± 0.37* | 234.20 ± 1.01* (78.07) | 65.80 ± 1.01* (21.93) |
MESC | 200 | 15.80 ± 0.37* | 15.20 ± 0.37* | 176.60 ± 2.61* (48.53) | 123.40 ± 2.61* (51.47) |
MESC | 400 | 21.20 ± 0.24* | 11.80 ± 0.37* | 202.00 ± 1.0* (67.33) | 98.00 ± 1.0* (32.67) |
MESC | 600 | 23.60 ± 0.74* | 10.20 ± 0.37* | 218.20 ± 2.14* (72.73) | 81.80 ± 2.14* (27.27) |