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International Journal of Phytomedicine and Phytotherapy

Table 5 The anxiolytic effect of MESC on light-dark box test in mice

From: Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice

Treatment Dose (mg/kg) Latency time (s) Transitions Time spent in the light box (s) Time spent in the dark Box (s)
Control 0.1 ml/mouse 12.20 ± 0.37 19.40 ± 0.50 123.80 ± 0.73 (41.27) 176.20 ± 0.73 (58.73)
Diazepam 1 26.40 ± 0.51* 8.80 ± 0.37* 234.20 ± 1.01* (78.07) 65.80 ± 1.01* (21.93)
MESC 200 15.80 ± 0.37* 15.20 ± 0.37* 176.60 ± 2.61* (48.53) 123.40 ± 2.61* (51.47)
MESC 400 21.20 ± 0.24* 11.80 ± 0.37* 202.00 ± 1.0* (67.33) 98.00 ± 1.0* (32.67)
MESC 600 23.60 ± 0.74* 10.20 ± 0.37* 218.20 ± 2.14* (72.73) 81.80 ± 2.14* (27.27)
  1. i. * p < 0.001 vs control group
  2. ii.** p < 0.0001 vs control group.
  3. # within bracket result expressed in percentage (%).