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International Journal of Phytomedicine and Phytotherapy

Table 4 ADME and toxic properties

From: Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract

ADME Toxicity
Compound name Chemspider ID HIA
(%)
PPB
(%)
BBB
(%)
Cacok2
(nm/sec)
Skin Permeability MDCK
(nm/sec)
Rodent Carcinogenicity
Carcino Mouse Carcino Rat
Silymarine 78.55 87.70 0.0596 7.852 −4.236 0.0691 negative negative
 I 106,997 75.91 38.437 0.273 1.85622 −4.75733 24.0956 negative negative
 II 26,000,801 89.88 2.783 0.511 7.647 −2.61671 158.521 negative positive
 II 10,246,715 20.28 6.595 0.428 8.27242 −4.96717 0.530 negative positive
  1. 2,3-Dihydro-3,5-dihydroxy-6-methyl-4 h-pyran-4-one (Compound I), 2-furancarboxaldehyde 5-(hydroxymethyl)-(Compound II), and Quinic acid (Compound III). HIA: human intestinal absorption, PPB: plasma protein binding, BBB: the blood-brain barrier