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International Journal of Phytomedicine and Phytotherapy

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Table 1 Effect of single dose of C. frutescens on serum glucose level and % reduction in diabetic rats

From: Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Time (hr) SERUM GLUCOSE (mg/dL) % REDUCTION
  C. frutescens (100 mg/kg) C. frutescens (200 mg/kg) C. frutescens (400 mg/kg) C. frutescens (100 mg/kg) C. frutescens (200 mg/kg) C. frutescens
(400 mg/kg)
0 309.17 ± 2.08 311.62 ± 2.09 307.38 ± 1.56
1 296.72 ± 3.59 296.20 ± 1.91 288.20 ± 1.85 4.02 ± 1.08** 4.94 ± 0.77*** 6.24 ± 0.64***
2 286.95 ± 3.15 285.38 ± 1.57 281.23 ± 1.17 7.18 ± 0.99*** 8.41 ± 0.79*** 8.50 ± 0.12**
3 277.33 ± 3.00 272.32 ± 2.83 266.33 ± 1.24 10.28 ± 1.15*** 12.60 ± 1.11*** 13.35 ± 0.61***
4 269.80 ± 2.95 259.18 ± 3.05 254.53 ± 2.72 12.71 ± 1.21*** 16.80 ± 1.32*** 17.17 ± 1.00***
6 261.72 ± 2.79 250.35 ± 2.91 239.25 ± 5.00 15.32 ± 1.15*** 19.63 ± 1.23*** 22.16 ± 1.65***
8 265.40 ± 2.75 258.77 ± 3.01 250.02 ± 4.16 14.14 ± 0.96*** 16.93 ± 1.31*** 18.67 ± 1.19***
10 272.43 ± 2.74 267.42 ± 3.44 262.35 ± 2.63 11.86 ± 1.01*** 14.47 ± 1.48*** 14.65 ± 0.82***
12 285.72 ± 1.90 275.80 ± 3.23 270.42 ± 2.00 7.57 ± 0.69*** 11.47 ± 1.44*** 12.02 ± 0.50***
16 293.28 ± 1.55 286.47 ± 1.60 280.15 ± 2.61 5.13 ± 0.57*** 8.06 ± 0.49*** 8.83 ± 1.20**
24 301.84 ± 2.22 298.70 ± 2.59 292.23 ± 1.76 2.37 ± 0.40* 4.14 ± 0.54*** 4.91 ± 0.75*
  1. n = 6, ns- non significant, significant at *P < 0.05, **P < 0.01, ***P < 0.001 when compared to control group