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International Journal of Phytomedicine and Phytotherapy

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Table 2 Antidiabetic activity of Glimepiride (GLIM) in diabetic rats

From: Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Time (hr) SERUM GLUCOSE (mg/dL) % REDUCTION
½ TD GLIM 1TD GLIM 2 TD GLIM ½ TD GLIM 1TD GLIM 2 TD GLIM
0 307.47 ± 2.89 304.98 ± 6.80 306.15 ± 5.12
1 291.43 ± 4.13 287.53 ± 6.70 270.89 ± 3.23 5.18 ± 1.57*** 5.69 ± 1.23*** 11.31 ± 2.48***
2 266.73 ± 3.51 261.10 ± 6.42 250.87 ± 5.80 13.24 ± 0.92*** 14.37 ± 1.26*** 18.06 ± 1.30***
3 241.17 ± 4.12 234.15 ± 3.69 223.65 ± 5.50 21.52 ± 1.61*** 23.14 ± 1.10*** 26.90 ± 1.76***
4 224.82 ± 2.94 200.07 ± 5.61 188.58 ± 6.10 26.87 ± 0.79*** 34.37 ± 1.14*** 38.43 ± 1.48***
6 205.67 ± 1.54 183.53 ± 3.91 157.18 ± 4.71 33.10 ± 0.45*** 39.79 ± 0.76*** 48.67 ± 1.20***
8 222.82 ± 5.28 189.47 ± 3.21 181.50 ± 3.76 27.55 ± 1.36*** 37.75 ± 1.51*** 40.66 ± 1.33***
10 229.10 ± 4.15 206.02 ± 5.50 201.92 ± 4.51 25.50 ± 0.97*** 32.36 ± 1.82*** 34.03 ± 1.11***
12 252.68 ± 4.37 235.18 ± 6.49 224.60 ± 4.47 17.80 ± 1.35*** 22.86 ± 1.53*** 26.57 ± 1.58***
16 269.00 ± 3.21 258.45 ± 6.56 241.93 ± 1.44 12.51 ± 0.72*** 15.26 ± 1.08*** 20.86 ± 1.43***
24 284.13 ± 4.78 274.15 ± 5.75 261.98 ± 7.00 7.60 ± 1.12*** 10.04 ± 1.47*** 14.46 ± 1.41***
  1. n = 6, ns- non significant, significant at *P < 0.05, **P < 0.01, ***P < 0.001 when compared to control group