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International Journal of Phytomedicine and Phytotherapy

Table 3 Influence of single dose treatment of C. frutescens (400 mg/kg) on antidiabetic activity of glimepiride in diabetic rats

From: Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Time (hr)

SERUM GLUCOSE (mg/dL)

% REDUCTION

 

400 mg C. frutescens

400 mg C. frutescens

 

½ TD GLIM

1TD GLIM

2 TD GLIM

½ TD GLIM

1TD GLIM

2 TD GLIM

0

322.05 ± 2.45

316.25 ± 2.67

305.40 ± 4.41

1

295.33 ± 3.89

286.65 ± 3.35

266.70 ± 2.70

8.29 ± 1.15ns

9.36 ± 0.79 ns

15.89 ± 1.92***###

2

272.58 ± 5.15

258.08 ± 2.74

241.87 ± 3.51

15.36 ± 1.50ns

18.38 ± 0.77*

20.65 ± 2.28***##

3

248.97 ± 3.85

235.38 ± 5.46

220.38 ± 3.34

22.69 ± 1.07ns

25.61 ± 1.16ns

27.07 ± 1.88***##

4

224.78 ± 3.12

199.03 ± 2.68

180.37 ± 3.66

30.19 ± 1.00ns$$$

37.05 ± 0.93***$$$

40.84 ± 1.78***##$

6

28.63 ± 2.40

183.98 ± 2.36

143.42 ± 3.60

35.22 ± 0.58ns#$$$

42.12 ± 0.92***$$$

52.95 ± 1.60***###$

8

224.95 ± 2.95

195.95 ± 5.09

165.58 ± 1.04

30.13 ± 1.10ns##$$$

38.01 ± 1.73***

45.71 ± 1.09***###

10

235.97 ± 3.39

213.27 ± 3.85

189.88 ± 1.94

26.67 ± 1.55ns#$$

32.52 ± 1.47**

39.35 ± 0.74***##$

12

250.0 ± 5.05

233.62 ± 3.90

213.70 ± 3.07

22.31 ± 2.01ns

26.10 ± 1.42***

31.72 ± 1.35***#

16

270.28 ± 4.84

252.57 ± 2.71

239.17 ± 3.13

16.04 ± 1.74ns$$$

20.12 ± 0.94***

23.61 ± 1.16***###

24

289.28 ± 2.65

262.98 ± 4.58

251.95 ± 4.03

10.18 ± 0.38ns

16.37 ± 1.10***

17.37 ± 2.13***###

  1. n = 6, ns- non significant, significant at *P < 0.05, **P < 0.01, ***P < 0.001 when compared to control group; nsP > 0.05, #P < 0.05, ##P < 0.01, ###P < 0.001 when compared to glimepiride ½ TD, 1TD and 2 TD group; when compared to glimepiride TD group