Skip to main content

International Journal of Phytomedicine and Phytotherapy

Clinical Phytoscience Cover Image

Table 3 Influence of single dose treatment of C. frutescens (400 mg/kg) on antidiabetic activity of glimepiride in diabetic rats

From: Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Time (hr) SERUM GLUCOSE (mg/dL) % REDUCTION
  400 mg C. frutescens 400 mg C. frutescens
  ½ TD GLIM 1TD GLIM 2 TD GLIM ½ TD GLIM 1TD GLIM 2 TD GLIM
0 322.05 ± 2.45 316.25 ± 2.67 305.40 ± 4.41
1 295.33 ± 3.89 286.65 ± 3.35 266.70 ± 2.70 8.29 ± 1.15ns 9.36 ± 0.79 ns 15.89 ± 1.92***###
2 272.58 ± 5.15 258.08 ± 2.74 241.87 ± 3.51 15.36 ± 1.50ns 18.38 ± 0.77* 20.65 ± 2.28***##
3 248.97 ± 3.85 235.38 ± 5.46 220.38 ± 3.34 22.69 ± 1.07ns 25.61 ± 1.16ns 27.07 ± 1.88***##
4 224.78 ± 3.12 199.03 ± 2.68 180.37 ± 3.66 30.19 ± 1.00ns$$$ 37.05 ± 0.93***$$$ 40.84 ± 1.78***##$
6 28.63 ± 2.40 183.98 ± 2.36 143.42 ± 3.60 35.22 ± 0.58ns#$$$ 42.12 ± 0.92***$$$ 52.95 ± 1.60***###$
8 224.95 ± 2.95 195.95 ± 5.09 165.58 ± 1.04 30.13 ± 1.10ns##$$$ 38.01 ± 1.73*** 45.71 ± 1.09***###
10 235.97 ± 3.39 213.27 ± 3.85 189.88 ± 1.94 26.67 ± 1.55ns#$$ 32.52 ± 1.47** 39.35 ± 0.74***##$
12 250.0 ± 5.05 233.62 ± 3.90 213.70 ± 3.07 22.31 ± 2.01ns 26.10 ± 1.42*** 31.72 ± 1.35***#
16 270.28 ± 4.84 252.57 ± 2.71 239.17 ± 3.13 16.04 ± 1.74ns$$$ 20.12 ± 0.94*** 23.61 ± 1.16***###
24 289.28 ± 2.65 262.98 ± 4.58 251.95 ± 4.03 10.18 ± 0.38ns 16.37 ± 1.10*** 17.37 ± 2.13***###
  1. n = 6, ns- non significant, significant at *P < 0.05, **P < 0.01, ***P < 0.001 when compared to control group; nsP > 0.05, #P < 0.05, ##P < 0.01, ###P < 0.001 when compared to glimepiride ½ TD, 1TD and 2 TD group; when compared to glimepiride TD group