Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Influence of repeated dose treatment of C. frutescens (400 mg/kg) on antidiabetic activity of glimepiride in diabetic rats (8th day)

From: Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Time (hr)	SERUM GLUCOSE (mg/dL)			% REDUCTION
	400 mg C. frutescens			400 mg C. frutescens
	½ TD GLIM	1TD GLIM	2 TD GLIM	½ TD GLIM	1TD GLIM	2 TD GLIM
0	307.80 ± 2.09	293.47 ± 3.14	298.67 ± 3.20	–	–	–
1	272.80 ± 1.62	257.30 ± 2.69	249.77 ± 2.91	11.35 ± 0.91^ns#	12.31 ± 0.69^***###	16.33 ± 1.14***###
2	255.85 ± 1.85	235.50 ± 3.14	226.03 ± 4.52	16.88 ± 0.25^ns	19.72 ± 1.26^*##	24.28 ± 1.69***###$$$
3	234.20 ± 2.48	211.52 ± 4.35	207.52 ± 2.14	23.91 ± 0.36^ns	27.94 ± 1.03^**#	30.47 ± 1.15***###
4	202.45 ± 1.79	181.68 ± 4.30	173.92 ± 4.51	34.21 ± 0.80^ns	38.10 ± 1.22^***	41.77 ± 1.14***###
6	192.78 ± 2.53	157.17 ± 4.85	139.60 ± 1.59	37.35 ± 0.91^ns$$$	46.14 ± 1.56^***##	53.27 ± 0.88***###
8	209.05 ± 2.29	173.96 ± 3.00	155.25 ± 3.17	32.08 ± 0.56^ns#$$$	40.71 ± 1.07^***$$	48.01 ± 1.00***###
10	222.03 ± 3.68	195.68 ± 1.99	183.33 ± 2.92	27.88 ± 0.83^ns$	33.31 ± 0.75^***###	38.61 ± 0.83***###
12	237.12 ± 4.45	211.05 ± 3.29	202.67 ± 3.10	22.98 ± 1.17^ns	28.07 ± 1.24^***	32.13 ± 0.82***###$
16	255.87 ± 4.45	228.60 ± 2.26	232.05 ± 2.46	16.87 ± 1.17^ns	22.08 ± 0.92^***##	22.27 ± 1.00***##
24	269.80 ± 3.61	245.45 ± 3.27	243.35 ± 3.35	12.34 ± 1.07^ns	16.99 ± 0.90^***##	18.47 ± 1.23***###

n = 6, ns- non significant, significant at *P < 0.05, **P < 0.01, ***P < 0.001 when compared to control group; ^nsP > 0.05, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 when compared to glimepiride ½ TD, 1TD and 2 TD group; when compared to glimepiride TD group; p < 0.05, p < 0.01 and $$ p<0.001, ns = not significant when compared with glimepiride 2 TD

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