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International Journal of Phytomedicine and Phytotherapy

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Table 4 Influence of repeated dose treatment of C. frutescens (400 mg/kg) on antidiabetic activity of glimepiride in diabetic rats (8th day)

From: Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Time (hr) SERUM GLUCOSE (mg/dL) % REDUCTION
400 mg C. frutescens 400 mg C. frutescens
½ TD GLIM 1TD GLIM 2 TD GLIM ½ TD GLIM 1TD GLIM 2 TD GLIM
0 307.80 ± 2.09 293.47 ± 3.14 298.67 ± 3.20
1 272.80 ± 1.62 257.30 ± 2.69 249.77 ± 2.91 11.35 ± 0.91ns# 12.31 ± 0.69***### 16.33 ± 1.14***###
2 255.85 ± 1.85 235.50 ± 3.14 226.03 ± 4.52 16.88 ± 0.25ns 19.72 ± 1.26*## 24.28 ± 1.69***###$$$
3 234.20 ± 2.48 211.52 ± 4.35 207.52 ± 2.14 23.91 ± 0.36ns 27.94 ± 1.03**# 30.47 ± 1.15***###
4 202.45 ± 1.79 181.68 ± 4.30 173.92 ± 4.51 34.21 ± 0.80ns 38.10 ± 1.22*** 41.77 ± 1.14***###
6 192.78 ± 2.53 157.17 ± 4.85 139.60 ± 1.59 37.35 ± 0.91ns$$$ 46.14 ± 1.56***## 53.27 ± 0.88***###
8 209.05 ± 2.29 173.96 ± 3.00 155.25 ± 3.17 32.08 ± 0.56ns#$$$ 40.71 ± 1.07***$$ 48.01 ± 1.00***###
10 222.03 ± 3.68 195.68 ± 1.99 183.33 ± 2.92 27.88 ± 0.83ns$ 33.31 ± 0.75***### 38.61 ± 0.83***###
12 237.12 ± 4.45 211.05 ± 3.29 202.67 ± 3.10 22.98 ± 1.17ns 28.07 ± 1.24*** 32.13 ± 0.82***###$
16 255.87 ± 4.45 228.60 ± 2.26 232.05 ± 2.46 16.87 ± 1.17ns 22.08 ± 0.92***## 22.27 ± 1.00***##
24 269.80 ± 3.61 245.45 ± 3.27 243.35 ± 3.35 12.34 ± 1.07ns 16.99 ± 0.90***## 18.47 ± 1.23***###
  1. n = 6, ns- non significant, significant at *P < 0.05, **P < 0.01, ***P < 0.001 when compared to control group; nsP > 0.05, #P < 0.05, ##P < 0.01, ###P < 0.001 when compared to glimepiride ½ TD, 1TD and 2 TD group; when compared to glimepiride TD group; p < 0.05, p < 0.01 and $$ p<0.001, ns = not significant when compared with glimepiride 2 TD