Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table. 6 Various pharmacokinetic parameters

Parameters	Glimepiride	Glipmepiride + C. frutescens (1st day interaction)	Glipmepiride + C. frutescens (15th day interaction)
C_max ng/mL	71.23 ± 23.22	70.98 ± 22.34	71.03 ± 36.33
T_max hours	3.6 ± 1.27	3.58 ± 0.98	3.43 ± 1.11
T_1/2 h	6.93 ± 2.10	6.81 ± 1.29	6.78 ± 2.32
AUC_{0-t (}ng/mL/hr)	1272 ± 34.45	1258 ± 46.79	1238 ± 41.85
AUC_{0-∞ (}ng/mL/hr)	162.62 ± 44.56	160.12 ± 21.65	161.32 ± 43.67