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International Journal of Phytomedicine and Phytotherapy

Table 2 Anti-pyretic effects of phytol and/or ascorbic acid and controls in Brewer’s yeast-induced pyrexia in mice

From: Ascorbic acid interaction with phytol: a modulatory effects on the anti-pyretic activity of paracetamol in Swiss albino mice

Treatment

Rectal temperature (°F)

Basal#

0 h (after 18 h##)

1 h###

2 h###

3 h###

4 h###

Gr-I: Control (n = 5)

98.50 ± 0.18

100.67 ± 0.23

100.77 ± 0.14

100.73 ± 0.09

100.63 ± 0.18

100.58 ± 0.27

Gr-II: PARA (n = 5)

98.46 ± 0.09

100.40 ± 0.09

98.47 ± 0.23*ac

99.37 ± 0.12*a

98.41 ± 0.31*a

98.46 ± 0.37*a

Gr-III: PHY (n = 5)

98.48 ± 0.11

100.48 ± 0.17

99.58 ± 0.09a

98.48 ± 0.23*a

98.38 ± 0.12*a

98.44 ± 0.09*a

Gr-IV: AA (n = 5)

97.27 ± 1.45

97.93 ± 1.49

98.07 ± 1.43a

98.04 ± 1.11a

97.93 ± 0.11a

97.83 ± 0.47a

Gr-V: PHY + AA (n = 5)

96.30 ± 0.58

97.37 ± 0.33

97.73 ± 0.69ac

96.33 ± 1.16*abcd

96.22 ± 0.49*abcd

97.31 ± 0.35abc

Gr-VI: PHY + PARA (n = 5)

98.46 ± 0.16

100.50 ± 0.11

98.47 ± 0.09*ac

98.45 ± 0.06*a

98.42 ± 0.09*a

98.47 ± 0.14*a

Gr-VII: AA + PARA (n = 5)

99.30 ± 0.35

99.90 ± 0.26

99.33 ± 0.35a

99.26 ± 0.18a

99.33 ± 0.15a

99.29 ± 0.20a

Gr-VIII: PHY + AA + PARA (n = 5)

99.93 ± 0.76

100.63 ± 0.22

99.83 ± 0.59a

99.85 ± 1.22a

99.89 ± 1.04a

99.92 ± 1.51a

  1. #Rectal temperature before fever induction, ##Rectal temperature after 18 h of fever induction, ###Time after treatment
  2. AA ascorbic acid, PARA paracetamol, PHY phytol. Values are mean ± SEM. Statistical analysis: ANOVA followed by Dunnett’s multiple comparisons p < 0.05 when compared to *0 h (respective group); acontrol, bPARA, cPHY, dAA
  3. Gr-I: Control (vehicle)
  4. Gr-II: PARA (100 mg/kg)
  5. Gr-III: PHY (200 mg/kg)
  6. Gr-IV: AA (125 mg/kg)
  7. Gr-V: PHY (200 mg/kg) + AA (125 mg/kg)
  8. Gr-VI: PHY (200 mg/kg) + PARA (100 mg/kg)
  9. Gr-VII: AA (125 mg/kg) + PARA (100 mg/kg)
  10. Gr-VIII: PHY (200 mg/kg) + AA (125 mg/kg) + PARA (100 mg/kg)