Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of ethanolic extract T. indica L. leaf on food intake and body weight of high-fat diet induced rats

Parameter	ND	HFD	HFD + TILE100	HFD + TILE200	HFD + TILE400
Food intake (g/day)	18.23 ± 2.51^a	18.51 ± 3.11^a	20.21 ± 2.42^a	19.41 ± 2.92^a	19.21 ± 2.67^a
Percent weight gain	39.82 ± 4.25^a	66.27 ± 5.42^b	62.91 ± 7.38^b	59.72 ± 5.32^b	45.26 ± 4.53^a
Liver weight (g/100 g body weight)	3.12 ± 0.43^a	4.83 ± 0.63^b	4.64 ± 0.54^b	4.52 ± 0.57^b	3.61 ± 0.61^a
Epidedymal fat (g/100 g body weight)	1.13 ± 0.12^a	1.81 ± 0.23^b	1.72 ± 0.18^b	1.64 ± 0.19^b	1.61 ± 0.17^b
Mesenteric fat (g/100 g body weight)	0.73 ± 0.08^a	1.17 ± 0.13^b	1.02 ± 0.12^b	0.97 ± 0.10^a	0.84 ± 0.11^a
Peritoneal fat (g/100 g body weight)	0.87 ± 0.10^a	1.26 ± 0.15^b	1.22 ± 0.11^b	1.17 ± 0.13^b	0.91 ± 0.12^a

Effects of Tamarindus indica L. leaf extract (TILE) on food intake, body weight gain, liver weight and adipose tissue weight in different group of Wistar rats fed with either of standard laboratory diet (SD), or high-fat diet (HFD), or HFD with TILE. TILE was given orally everyday throughout the study period either in low dose (HFD + TILE100), or intermediate dose (HFD + TILE200) or high dose (HFD + TILE400). Data was analyzed by one way ANOVA followed by Newman-Keuls’s post-hoc test and expressed as mean ± SEM (n = 6). Values with different superscript letters within the same row are significantly different at p < 0.05