Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Effect of high-fat diet and ethanolic extract of T. indica L. leaf on lipid profile of rats

Parameter	ND	HFD	HFD + TILE100	HFD + TILE200	HFD + TILE400
TG (mg/dl)	121.81 ± 13.33^a	216.37 ± 21.57^b	211.42 ± 22.17^b	199.43 ± 23.63^b	145.82 ± 19.23^a
TC (mg/dl)	198.21 ± 23.84^a	274.23 ± 25.34^b	268.05 ± 31.34^b	242.54 ± 34.39^b	205.35 ± 24.47^a
HDL-C (mg/dl)	62.33 ± 6.72^a	41.27 ± 6.98^b	47.64 ± 7.45^b	50.67 ± 5.43^b	51.31 ± 6.53^b
LDL-C (mg/dl)	111.27 ± 14.58^a	189.71 ± 17.32^b	178.87 ± 19.37^b	152.21 ± 19.34^a	125.56 ± 14.49^a
VLDL-C (mg/dl)	24.52 ± 3.65^a	43.34 ± 5.67^b	42.13 ± 6.37^b	39.72 ± 5.43^b	29.22 ± 4.51^a
AI	2.19 ± 0.21^a	5.65 ± 0.71^b	4.58 ± 0.63^b	3.84 ± 0.34^c	3.05 ± 0.42^c
CRI	3.19 ± 0.61^a	6.65 ± 0.81^b	5.58 ± 0.71^b	4.84 ± 0.37^c	4.05 ± 0.54^a

Effects of T. indica L. leaf extract (TILE) on lipid related parameters in different group of Wistar rats fed with either of standard laboratory diet (SD), or high-fat diet (HFD), or HFD with TILE. TILE was given orally everyday throughout the study period either in low dose (HFD + TILE100), or intermediate dose (HFD + TILE200) or high dose (HFD + TILE400). Data was analyzed by one way ANOVA followed by Newman-Keuls’s post-hoc test and expressed as mean ± SEM (n = 6). Values with different superscript letters within the same row are significantly different at p < 0.05