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International Journal of Phytomedicine and Phytotherapy

Table 4 Binding affinities of phytochemicals with α-amylase and α-glucosidase enzymes

From: Identification of bioactive compounds by GC-MS and α-amylase and α-glucosidase inhibitory activity of Rauvolfia tetraphylla L. and Oroxylum indicum (L.) Kurz: an in vitro and in silico approach

Name of compounds

α-amylase

(kcal/mol)

α-glucosidase (kcal/mol)

Acarbose, reference inhibitor

−8.1

−7.2

8-(Dimethylamino)-7-(3-(4-ethylphenoxy)-2-hydroxypropyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione tms

−7.4

−7.2

Chlorflurenol

−7.6

−6.1

2-(4-Nitro-pyrazol-1-yl) propionic acid, hydrazide

−6.1

−6.4

9-(2-Methoxyethyl) carbazole

−6.5

−5.4

Benzo [B] thiophene, octahydro-2-methyl- (2.alpha., 3a.beta., 7a.beta.)-

−5.4

−4.5

2-Benzimidazolemethanol, .alpha.-(p-bromophenyl)-

−7.3

−7.2

Tricyclo[8.4.1.1 (4,9)]hexadeca-4,6,8,10,12,14-hexaene, 2,3-bis(2,6-dimethylphenylimino)-, anti-

−7.4

−8.5

1-(3′,5′-Dibromo-4′-hydroxyphenyl)-5,5-dibromo-2,4-dioxohexahydropyrimidine

−6.4

−5.6

Dithiocarbamate, S-methyl-, N-(2,3-dimethyl-4-oxo-2-pentyl)-

−4.6

− 4.7

Pregnane-3,7,20-trione, (5.alpha.)-

−9.2

− 7.3

Methylenebis (ethyl thioglycolate)

−4.5

−5.0