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International Journal of Phytomedicine and Phytotherapy

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Table 4 Binding affinities of phytochemicals with α-amylase and α-glucosidase enzymes

From: Identification of bioactive compounds by GC-MS and α-amylase and α-glucosidase inhibitory activity of Rauvolfia tetraphylla L. and Oroxylum indicum (L.) Kurz: an in vitro and in silico approach

Name of compounds α-amylase
(kcal/mol)
α-glucosidase (kcal/mol)
Acarbose, reference inhibitor −8.1 −7.2
8-(Dimethylamino)-7-(3-(4-ethylphenoxy)-2-hydroxypropyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione tms −7.4 −7.2
Chlorflurenol −7.6 −6.1
2-(4-Nitro-pyrazol-1-yl) propionic acid, hydrazide −6.1 −6.4
9-(2-Methoxyethyl) carbazole −6.5 −5.4
Benzo [B] thiophene, octahydro-2-methyl- (2.alpha., 3a.beta., 7a.beta.)- −5.4 −4.5
2-Benzimidazolemethanol, .alpha.-(p-bromophenyl)- −7.3 −7.2
Tricyclo[8.4.1.1 (4,9)]hexadeca-4,6,8,10,12,14-hexaene, 2,3-bis(2,6-dimethylphenylimino)-, anti- −7.4 −8.5
1-(3′,5′-Dibromo-4′-hydroxyphenyl)-5,5-dibromo-2,4-dioxohexahydropyrimidine −6.4 −5.6
Dithiocarbamate, S-methyl-, N-(2,3-dimethyl-4-oxo-2-pentyl)- −4.6 − 4.7
Pregnane-3,7,20-trione, (5.alpha.)- −9.2 − 7.3
Methylenebis (ethyl thioglycolate) −4.5 −5.0