An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of polyherbal combination (PHC) on physical and behavioral parameter in mice during 14-day acute toxicity study

Parameter	Normal control	250 mg/kg/day	500 mg/kg/day	1000 mg/kg/day	2000 mg/kg/day
Parameter	NC	TG1	TG2	TG3	TG4
Body weight	21 g	21 g	21 g	21 g	21 g
Food consumption (24 h)	38 g	40 g	42 g	38 g	44 g
Water consumption for 24 h	22 ml	23 ml	20 ml	22 ml	22 ml
Body temperature	Normal	Normal	Normal	Normal	Normal
Visible abnormalities	NIL	NIL	NIL	NIL	NIL
Rate of respiration	Normal	Normal	Normal	Normal	Normal
Drowsiness	Not observed	Not observed	Not observed	Not observed	Not observed
Lethargy	Not observed	Not observed	Not observed	Not observed	Not observed
Stool colour	Dark Black	Dark Black	Dark Black	Dark Black	Dark Black
Urination	Normal	Normal	Normal	Normal	Normal
Diarrhoea	NIL	NIL	NIL	NIL	NIL
Mucoid stool	NIL	NIL	NIL	NIL	NIL
Eye colour / Pigmentation	Normal	Normal	Normal	Normal	Normal
Skin colour	Normal	Normal	Normal	Normal	Normal
Rashes	Not seen	Not seen	Not seen	Not seen	Not seen
Mobility	34 mins.	35 mins	32 mins.	35 mins.	33 mins.
Paw jumping	NIL	NIL	NIL	NIL	NIL
Paw licking	Not seen	Not seen	Not seen	Not seen	Not seen
Paw biting	Not observed	Not observed	Not observed	Not observed	Not observed
Mortality	Alive	Alive	Alive	Alive	Alive