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International Journal of Phytomedicine and Phytotherapy

Table 2 Effect of polyherbal combination (PHC) on physical and behavioral parameter in mice during 14-day acute toxicity study

From: An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Parameter Normal control 250 mg/kg/day 500 mg/kg/day 1000 mg/kg/day 2000 mg/kg/day
NC TG1 TG2 TG3 TG4
Body weight 21 g 21 g 21 g 21 g 21 g
Food consumption (24 h) 38 g 40 g 42 g 38 g 44 g
Water consumption for 24 h 22 ml 23 ml 20 ml 22 ml 22 ml
Body temperature Normal Normal Normal Normal Normal
Visible abnormalities NIL NIL NIL NIL NIL
Rate of respiration Normal Normal Normal Normal Normal
Drowsiness Not observed Not observed Not observed Not observed Not observed
Lethargy Not observed Not observed Not observed Not observed Not observed
Stool colour Dark Black Dark Black Dark Black Dark Black Dark Black
Urination Normal Normal Normal Normal Normal
Diarrhoea NIL NIL NIL NIL NIL
Mucoid stool NIL NIL NIL NIL NIL
Eye colour / Pigmentation Normal Normal Normal Normal Normal
Skin colour Normal Normal Normal Normal Normal
Rashes Not seen Not seen Not seen Not seen Not seen
Mobility 34 mins. 35 mins 32 mins. 35 mins. 33 mins.
Paw jumping NIL NIL NIL NIL NIL
Paw licking Not seen Not seen Not seen Not seen Not seen
Paw biting Not observed Not observed Not observed Not observed Not observed
Mortality Alive Alive Alive Alive Alive