An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of polyherbal combination (PHC) on average organ weight (g) of mice

Organ	Average organ weight (gm)
	Distilled water	250 mg/kg/day	500 mg/kg/day	1000 mg/kg/day	2000 mg/kg/day
	NCX	TX1	TX2	TX3	TX4
Brain	0.398 ± 0.046	0.393 ± 0.039	0.397 ± 0.400	0.4 ± 0.045	0.392 ± 0.046
Heart	0.186 ± 0.007	0.184 ± 0.002	0.188 ± 0.012	0.188 ± 0.009	0.186 ± 0.007
Kidney (L + R)	0.265 ± 0.009	0.265 ± 0.010	0.31 ± 0.065	0.268 ± 0.013	0.267 ± 0.013
Liver	1.278 ± 0.031	1.282 ± 0.032	1.283 ± 0.035	1.28 ± 0.035	1.284 ± 0.033
Lung	0.275 ± 0.010	0.281 ± 0.012	0.281 ± 0.003	0.276 ± 0.010	0.276 ± 0.009
Weight of animal on the day of sacrifice	21.273 ± 1.172	21.69 ± 0.378	22.067 ± 0.943	22.15 ± 1.089	21.25 ± 1.110

The values were depicted as means ± SD for 5 mice per group. Statistically significant differences between groups were measured using one-way ANOVA with nonparametric paired t- test. The values in different treated groups were found to be non-significant (p > 0.05) when compared with normal control group (NCX)