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International Journal of Phytomedicine and Phytotherapy

Table 8 Effect of polyherbal combination (PHC) on kidney function test

From: An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

Organ Kidney function test
Distilled water 250 mg/kg/day 500 mg/kg/day 1000 mg/kg/day 2000 mg/kg/day
NCX TX1 TX2 TX3 TX4
Total Bilirubin (mg/dL) 0.513 ± 0.031 0.513 ± 0.031 0.543 ± 0.050 0.527 ± 0.025 0.513 ± 0.038
Glucose (mg/dL) 133.667 ± 6.807 135 ± 5.240 135.687 ± 6.846*** 135.303 ± 4.559 134.31 ± 3.822
BUN (mg/dL) 16.53 ± 0.407 16.553 ± 0.323 16.703 ± 0.355 16.633 ± 0.224 16.31 ± 0.375
Creatinine (mg/dL) 0.44 ± 0.111 0.463 ± 0.105 0.470 ± 0.135 0.477 ± 0.106* 0.437 ± 0.129
Sodium (mmol/L) 134.51 ± 1.43 133.63 ± 0.88 135.82 ± 1.05 134.12 ± 1.53 136.47 ± 1.83
Urea (mg/dL) 47.84 ± 2.44 46.91 ± 1.69 46.07 ± 2.19 47.99 ± 1.89 48.53 ± 2.59
Uric acid (mg/dL) 2.04 ± 0.41 2.33 ± 0.52 2.67 ± 0.69 2.61 ± 0.24 2.83 ± 0.84
  1. The values were depicted as means ± SD for 5 mice per group. Statistically significant differences between groups were measured using one-way ANOVA with nonparametric paired t- test
  2. Where ***p < 0.001, highly significant; *p < 0.05, significant when the values was compared with normal control group (NCX)