International Journal of Phytomedicine and Phytotherapy
Sr. No | Model | Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 |
---|---|---|---|---|---|---|---|
Co-administration | |||||||
Biological Experimental Model | Normal Control | Inducer Control (Only) | Standard Treatment | Extract Treatment Dose 1 | Extract Treatment Dose 2 | Extract Treatment Dose 3 | |
1. | Carbon Tetrachloride (CCl4) induced hepatotoxicity. | Only HBSS | CCl4 2 mL/kg (in 0.5% Tween 80 Solution) | CCl4 2 mL/kg (in 0.5% Tween 80 Solution) | CCl4 2 mL/kg (in 0.5% Tween 80 Solution) | CCl4 2 mL/kg (in 0.5% Tween 80 Solution) | CCl4 2 mL/kg (in 0.5% Tween 80 Solution) |
Silymarin (500 mg/kg) | Ethanol fruit extract, 100 mg/kg | Ethanol fruit extract, 250 mg/kg | Ethanol fruit extract, 500 mg/kg | ||||
2. | Acetaminophen induced hepatotoxicity | Only HBSS | Acetaminophen (7 g/kg) | Acetaminophen (7 g/kg) | Acetaminophen (7 g/kg) | Acetaminophen (7 g/kg) | Acetaminophen (7 g/kg) |
Silymarin (500 mg/kg) | Ethanol fruit extract, 100 mg/kg | Ethanol fruit extract, 250 mg/kg | Ethanol fruit extract, 500 mg/kg | ||||
3. | Erythromycin induced hepatotoxicity | Only HBSS | Erythromycin (1.4 g/kg) | Erythromycin (1.4 g/kg) | Erythromycin (1.4 g/kg) | Erythromycin (1.4 g/kg) | Erythromycin (1.4 g/kg) |
Silymarin (500 mg/kg) | Ethanol fruit extract, 100 mg/kg | Ethanol fruit extract, 250 mg/kg | Ethanol fruit extract, 500 mg/kg |