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International Journal of Phytomedicine and Phytotherapy

Table 3 Experimental Design/ Biological Models

From: A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Sr.
No
Model Group 1 Group 2 Group 3 Group 4 Group 5 Group 6
Co-administration
  Biological Experimental Model Normal Control Inducer Control (Only) Standard Treatment Extract Treatment Dose 1 Extract Treatment Dose 2 Extract Treatment Dose 3
1. Carbon Tetrachloride (CCl4) induced hepatotoxicity. Only HBSS CCl4 2 mL/kg (in 0.5% Tween 80 Solution) CCl4 2 mL/kg (in 0.5% Tween 80 Solution) CCl4 2 mL/kg (in 0.5% Tween 80 Solution) CCl4 2 mL/kg (in 0.5% Tween 80 Solution) CCl4 2 mL/kg (in 0.5% Tween 80 Solution)
   Silymarin (500 mg/kg) Ethanol fruit extract, 100 mg/kg Ethanol fruit extract, 250 mg/kg Ethanol fruit extract, 500 mg/kg
2. Acetaminophen induced hepatotoxicity Only HBSS Acetaminophen (7 g/kg) Acetaminophen (7 g/kg) Acetaminophen (7 g/kg) Acetaminophen (7 g/kg) Acetaminophen (7 g/kg)
   Silymarin (500 mg/kg) Ethanol fruit extract, 100 mg/kg Ethanol fruit extract, 250 mg/kg Ethanol fruit extract, 500 mg/kg
3. Erythromycin induced hepatotoxicity Only HBSS Erythromycin (1.4 g/kg) Erythromycin (1.4 g/kg) Erythromycin (1.4 g/kg) Erythromycin (1.4 g/kg) Erythromycin (1.4 g/kg)
   Silymarin (500 mg/kg) Ethanol fruit extract, 100 mg/kg Ethanol fruit extract, 250 mg/kg Ethanol fruit extract, 500 mg/kg
  1. Note: After processing, all the test tubes or vials were kept in a BOD incubator at 37 °C overnight to mimic the body temperature