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International Journal of Phytomedicine and Phytotherapy

Table 3 Experimental Design/ Biological Models

From: A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Sr.

No

Model

Group 1

Group 2

Group 3

Group 4

Group 5

Group 6

Co-administration

 

Biological Experimental Model

Normal Control

Inducer Control (Only)

Standard Treatment

Extract Treatment Dose 1

Extract Treatment Dose 2

Extract Treatment Dose 3

1.

Carbon Tetrachloride (CCl4) induced hepatotoxicity.

Only HBSS

CCl4 2 mL/kg (in 0.5% Tween 80 Solution)

CCl4 2 mL/kg (in 0.5% Tween 80 Solution)

CCl4 2 mL/kg (in 0.5% Tween 80 Solution)

CCl4 2 mL/kg (in 0.5% Tween 80 Solution)

CCl4 2 mL/kg (in 0.5% Tween 80 Solution)

  

Silymarin (500 mg/kg)

Ethanol fruit extract, 100 mg/kg

Ethanol fruit extract, 250 mg/kg

Ethanol fruit extract, 500 mg/kg

2.

Acetaminophen induced hepatotoxicity

Only HBSS

Acetaminophen (7 g/kg)

Acetaminophen (7 g/kg)

Acetaminophen (7 g/kg)

Acetaminophen (7 g/kg)

Acetaminophen (7 g/kg)

  

Silymarin (500 mg/kg)

Ethanol fruit extract, 100 mg/kg

Ethanol fruit extract, 250 mg/kg

Ethanol fruit extract, 500 mg/kg

3.

Erythromycin induced hepatotoxicity

Only HBSS

Erythromycin (1.4 g/kg)

Erythromycin (1.4 g/kg)

Erythromycin (1.4 g/kg)

Erythromycin (1.4 g/kg)

Erythromycin (1.4 g/kg)

  

Silymarin (500 mg/kg)

Ethanol fruit extract, 100 mg/kg

Ethanol fruit extract, 250 mg/kg

Ethanol fruit extract, 500 mg/kg

  1. Note: After processing, all the test tubes or vials were kept in a BOD incubator at 37 °C overnight to mimic the body temperature