International Journal of Phytomedicine and Phytotherapy
From: Evidence-based management of acute rhinosinusitis with herbal products
Study | Study design | Population | Sample size | Main findings |
---|---|---|---|---|
Bahtouee M, et al. 2017 [54] | Double-blind controlled trial | Subacute sinusitis confirmed with CT | n = 18 with acetylcysteine n = 21 with placebo | Main study outcome: No differences between groups were observed on the Lund-Mackay score after treatment |
Macchi A, et al. 2012 [8] | Single-blind randomized trial | Patients with recurrent acute rhinosinusitis | n = 75 with ambroxol and flunisolide n = 75 with N-acetylcysteine and flunisolide | Primary outcome All the symptoms assessed in the clinical efficacy analysis had a severity reduction in both treatment groups Exploratory analysis: In the ITT population, the proportion of patients presenting an improvement at the end of treatment was 82.67% vs. 50.67% in the N-acetylcysteine and ambroxol groups, respectively (p < 0.0001) |