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International Journal of Phytomedicine and Phytotherapy

Table 7 Clinical studies of N-acetylcysteine

From: Evidence-based management of acute rhinosinusitis with herbal products

Study Study design Population Sample size Main findings
Bahtouee M, et al. 2017 [54] Double-blind controlled trial Subacute sinusitis confirmed with CT n = 18 with acetylcysteine
n = 21 with placebo
Main study outcome:
No differences between groups were observed on the Lund-Mackay score after treatment
Macchi A, et al. 2012 [8] Single-blind randomized trial Patients with recurrent acute rhinosinusitis n = 75 with ambroxol and flunisolide
n = 75 with N-acetylcysteine and flunisolide
Primary outcome
All the symptoms
assessed in the clinical efficacy analysis had a severity reduction in both treatment groups
Exploratory analysis:
In the ITT population, the proportion of patients presenting an improvement at the end of treatment was 82.67% vs. 50.67% in the N-acetylcysteine and ambroxol groups, respectively (p < 0.0001)
  1. CT Computed tomography, ITT Intent-to-treat