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International Journal of Phytomedicine and Phytotherapy

Fig. 1 | Clinical Phytoscience

Fig. 1

From: Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Fig. 1

Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. × 400). The Portal triad (blue arrow) composed of the hepatic vein and artery as well as the bile duct (PT), the well distributed hepatocytes (H) (yellow arrow) and hepatic sinusoids (black arrow) are demonstrated across study groups. Control treatment showed normal central venules without congestion, the morphology of the hepatocytes appear normal, the sinusoids appear normal with no observable form of infiltration and no observable pathological lesion seen. 50 mg/kg-1200 mg/kg treatments relative to control showed varied degree of hepatic injury that is dose dependent. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). Summarily, experimental group shows some degenerative changes that can be termed as necrosis, some mild fibrosis and hemorrhage characterized by the presences of infiltrated red hemorrhagic and inflammatory cells. Also observed is a distortion in the walls of the blood vessels (red arrow), pyknotic hepatocytes and signs of inflammation (red arrow)

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