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International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of ethanol extracts of J. carnea leaf on hematology parameters

From: Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Group

Control

50 mg/kg

100 mg/kg

500 mg/kg

800 mg/kg

1200 mg/kg

Parameters

WBC (*109/L)

22.35 ± 2.34

16.17 ± 1.90*

13.20 ± 1.91*

17.55 ± 1.18

20.10 ± 1.10

15.65 ± 1.76*

LYM (%)

82.85 ± 3.84

78.25 ± 2.45

85.10 ± 1.56

72.65 ± 6.90

73.5 ± 1.44

83.75 ± 1.41

MID (%)

10.10 ± 1.59

10.40 ± 0.12

10.65 ± 1.47

15.35 ± 2.92*

17.5 ± 1.67*

9.75 ± 0.10

GRAN (%)

7.10 ± 2.25

11.35 ± 1.30

4.25 ± 0.09

12.00 ± 3.98

9.00 ± 0.23

6.50 ± 1.33

RBC (*1012/L)

5.42 ± 1.27

4.46 ± 2.19

5.32 ± 1.16

7.81 ± 0.25*

8.00 ± 0.36*

7.50 ± 0.06*

HGB (g/dL)

13.03 ± 0.72

13.60 ± 1.04

14.00 ± 0.23

14.05 ± 0.95

14.20 ± 0.52*

13.95 ± 0.66

PLT (*109/L)

422.50 ± 33.20

532.67 ± 74.19

689.50 ± 1.44*

719.00 ± 95.84*

637.00 ± 54.27*

630.00 ± 56.58*

PCV (%)

34.20 ± 5.83

37.00 ± 12.47

34.95 ± 5.17

43.70 ± 1.21

45.60 ± 1.15

43.70 ± 1.39

MCV (fL)

66.55 ± 4.88

70.45 ± 6.61

69.40 ± 5.37

56.10 ± 0.23

56.70 ± 1.44

56.25 ± 1.07

MCH (pg)

27.10 ± 5.14

95.77 ± 6.22*

31.00 ± 7.22

17.90 ± 0.64

17.70 ± 0.17

17.90 ± 0.64

MCHC (g/dL)

39.75 ± 4.82

104.05 ± 10.70*

43.10 ± 7.04

32.00 ± 1.27

31.40 ± 0.52

31.80 ± 0.52

  1. Data are presented as mean ± SEM in n = 5 determinations. Values with asterisk (*) between groups indicate significant difference (p < 0.05) compared to control
  2. WBC white blood cell count: LYM lymphocyte count: MID Mid – sized cell: GRAN granulocyte Count: RBC red blood cell count: HGB hemoglobin: PLT platelet count: PCV packed cell volume: MCV mean corpuscular volume: MCH mean corpuscular haemoglobin and MCHC mean corpuscular haemoglobin concentration