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International Journal of Phytomedicine and Phytotherapy

Table 3 Effects of ethanol extracts of J. carnea leaf on hematology parameters

From: Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Group Control 50 mg/kg 100 mg/kg 500 mg/kg 800 mg/kg 1200 mg/kg
Parameters
WBC (*109/L) 22.35 ± 2.34 16.17 ± 1.90* 13.20 ± 1.91* 17.55 ± 1.18 20.10 ± 1.10 15.65 ± 1.76*
LYM (%) 82.85 ± 3.84 78.25 ± 2.45 85.10 ± 1.56 72.65 ± 6.90 73.5 ± 1.44 83.75 ± 1.41
MID (%) 10.10 ± 1.59 10.40 ± 0.12 10.65 ± 1.47 15.35 ± 2.92* 17.5 ± 1.67* 9.75 ± 0.10
GRAN (%) 7.10 ± 2.25 11.35 ± 1.30 4.25 ± 0.09 12.00 ± 3.98 9.00 ± 0.23 6.50 ± 1.33
RBC (*1012/L) 5.42 ± 1.27 4.46 ± 2.19 5.32 ± 1.16 7.81 ± 0.25* 8.00 ± 0.36* 7.50 ± 0.06*
HGB (g/dL) 13.03 ± 0.72 13.60 ± 1.04 14.00 ± 0.23 14.05 ± 0.95 14.20 ± 0.52* 13.95 ± 0.66
PLT (*109/L) 422.50 ± 33.20 532.67 ± 74.19 689.50 ± 1.44* 719.00 ± 95.84* 637.00 ± 54.27* 630.00 ± 56.58*
PCV (%) 34.20 ± 5.83 37.00 ± 12.47 34.95 ± 5.17 43.70 ± 1.21 45.60 ± 1.15 43.70 ± 1.39
MCV (fL) 66.55 ± 4.88 70.45 ± 6.61 69.40 ± 5.37 56.10 ± 0.23 56.70 ± 1.44 56.25 ± 1.07
MCH (pg) 27.10 ± 5.14 95.77 ± 6.22* 31.00 ± 7.22 17.90 ± 0.64 17.70 ± 0.17 17.90 ± 0.64
MCHC (g/dL) 39.75 ± 4.82 104.05 ± 10.70* 43.10 ± 7.04 32.00 ± 1.27 31.40 ± 0.52 31.80 ± 0.52
  1. Data are presented as mean ± SEM in n = 5 determinations. Values with asterisk (*) between groups indicate significant difference (p < 0.05) compared to control
  2. WBC white blood cell count: LYM lymphocyte count: MID Mid – sized cell: GRAN granulocyte Count: RBC red blood cell count: HGB hemoglobin: PLT platelet count: PCV packed cell volume: MCV mean corpuscular volume: MCH mean corpuscular haemoglobin and MCHC mean corpuscular haemoglobin concentration