Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 4 Effects of JCEE on protein and antioxidant system in liver and kidney of healthy wistar rats

Groups	Organ	Total protein (g/l)	GSH (μmol/g of protein)	CAT (U/g of protein)	SOD (U/g of protein)	MDA (μmol/g of protein) × 10³
Control (1 ml dH₂O)	Liver	50.86 ± 3.99	0.87 ± 0.11	3.00 ± 0.10	1.97 ± 1.08	29.81 ± 4.84
Control (1 ml dH₂O)	Kidney	61.49 ± 19.91	1.09 ± 0.37	3.08 ± 1.24	4.25 ± 0.58	16.19 ± 3.76
50 (mg/kg)	Liver	50.52 ± 8.74	0.84 ± 0.06	3.57 ± 1.74	2.36 ± 0.74	26.15 ± 2.36
50 (mg/kg)	Kidney	52.85 ± 8.59	0.71 ± 0.14	3.98 ± 1.07	3.21 ± 0.44	20.01 ± 3.03
100 (mg/kg)	Liver	49.53 ± 2.72	0.48 ± 0.09	1.91 ± 0.95	2.51 ± 1.42	27.66 ± 10.49
100 (mg/kg)	Kidney	49.86 ± 4.35	0.61 ± 0.09	3.57 ± 0.14	1.44 ± 0.52	15.17 ± 4.05
500 (mg/kg)	Liver	43.54 ± 3.32	0.68 ± 0.19	3.37 ± 0.83	3.79 ± 0.59	42.85 ± 5.49
500 (mg/kg)	Kidney	49.19 ± 1.33	0.99 ± 0.17	3.10 ± 0.58	4.56 ± 1.62	19.05 ± 8.45
800 (mg/kg)	Liver	42.89 ± 2.64	0.78 ± 0.08	2.93 ± 0.13	3.53 ± 1.29	43.70 ± 4.28
800 (mg/kg)	Kidney	50.19 ± 2.66	0.85 ± 0.16	3.83 ± 0.27	1.00 ± 0.35*	23.01 ± 8.86
1200 (mg/kg)	Liver	38.22 ± 3.52*	0.86 ± 0.19	3.65 ± 0.81	5.38 ± 2.06*	48.98 ± 5.66 *
1200 (mg/kg)	Kidney	52.85 ± 3. 50	0.48 ± 0.02*	3.80 ± 0.47	3.97 ± 3.56	23.35 ± 8.33

Data are presented as mean ± SEM: n = 5 determinations. Values with asterisk (*) in the same column indicate significant difference (p < 0.05) compared to control