International Journal of Phytomedicine and Phytotherapy
Table 1 Summary of studies on herbal-antimalarial drugs interactions using P. berghei model
From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs
S/no | Medicinal plant | Conventional antimalarial drug | Interaction effect | Reference |
|---|---|---|---|---|
1 | Methanol leaf extract of VA (125 mg/kg) | ART (2.86 and 35.14 mg/kg | High dose of ART antagonized VA | [25] |
2 | Gynostemma pentaphyllum and Moringa oleifera (500, 1000 and 2000 mg/kg) | ART (6 mg/kg) | Greater antimalarial activity was recorded. | [10] |
3 | Kaempferol (20 mg/kg) | CQ (10 mg/kg) | ↓ in parasitemia | [5] |
4 | Aqueous root extract of Cryptolepis sanguinolenta (36 mg/kg) | ART (2.5 mg/kg) | Extract ↓effectiveness of ART. | [13] |
5 | Hydroalcoholic fruit extract of Balanites aegyptiaca and leaf latex of Aloe camperi | CQ (12.5 mg/kg) | ↑ in parasitemia suppression ability of CQ | [23] |
6 | Aqueous fresh leaf extract of A. indica (100, 500, and 1000 mg/kg) | ART (6, 15, and 20 mg/kg) | A significant reduction in parasitemia | [26] |
7 | Methanol extracts of 15 Kenya medicinal plants, from 11 families | CQ (Dose not specified) | Improved suppressions of parasitemia | [27] |
8 | Hot water extract of 18 Kenya medicinal plants | CQ (Dose not specified) | Improved suppressions of parasitemia | [28] |
9 | Aqueous extracts of Morinda morindiodes (Mm) root, Morinda (Ml) lucida leaf and VA leaf | ART (10 mg/kg) | Mm and Ml extract ↓effectiveness of ART, but ART ↑effectiveness of VA | [29] |
10 | 216 extracts from 50 Western Ghats plants | CQ (Dose not specified) | Moderate to high in vivo antimalarial activity | [30] |
11 | Carica papaya leaf (50 mg/kg) | ART (15 mg/kg) | Antagonism | [31] |