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International Journal of Phytomedicine and Phytotherapy

Table 1 Summary of studies on herbal-antimalarial drugs interactions using P. berghei model

From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

S/no Medicinal plant Conventional antimalarial drug Interaction effect Reference
1 Methanol leaf extract of VA (125 mg/kg) ART (2.86 and 35.14 mg/kg High dose of ART antagonized VA [25]
2 Gynostemma pentaphyllum and Moringa oleifera (500, 1000 and 2000 mg/kg) ART (6 mg/kg) Greater antimalarial activity was recorded. [10]
3 Kaempferol (20 mg/kg) CQ (10 mg/kg) ↓ in parasitemia [5]
4 Aqueous root extract of Cryptolepis sanguinolenta (36 mg/kg) ART (2.5 mg/kg) Extract ↓effectiveness of ART. [13]
5 Hydroalcoholic fruit extract of Balanites aegyptiaca and leaf latex of Aloe camperi CQ (12.5 mg/kg) ↑ in parasitemia suppression ability of CQ [23]
6 Aqueous fresh leaf extract of A. indica (100, 500, and 1000 mg/kg) ART (6, 15, and 20 mg/kg) A significant reduction in parasitemia [26]
7 Methanol extracts of 15 Kenya medicinal plants, from 11 families CQ (Dose not specified) Improved suppressions of parasitemia [27]
8 Hot water extract of 18 Kenya medicinal plants CQ (Dose not specified) Improved suppressions of parasitemia [28]
9 Aqueous extracts of Morinda morindiodes (Mm) root, Morinda (Ml) lucida leaf and VA leaf ART (10 mg/kg) Mm and Ml extract ↓effectiveness of ART, but ART ↑effectiveness of VA [29]
10 216 extracts from 50 Western Ghats plants CQ (Dose not specified) Moderate to high in vivo antimalarial activity [30]
11 Carica papaya leaf (50 mg/kg) ART (15 mg/kg) Antagonism [31]
  1. Vernonia amygdalina (VA); Artesunate (ART); Plasmodium berghei (P.berghei); Chloroquine (CQ).↓ (Decreased activity), ↑ (Increased activity)