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International Journal of Phytomedicine and Phytotherapy

Table 3 Summary of studies on herbal-antimalarial drug interactions in normal animals (mice, rats and rabbits)

From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

S/no Medicinal plant Conventional antimalarial drug Animal Interaction effect Reference
1 Aqueous root extract of Cryptolepis sanguinolenta (36 g/kg) ART (150 mg/kg) Rats Cryptolepis sanguinolenta decreases the effectiveness of ART [35]
2 VA (250 and 500 mg/kg) Dihydroartemisinin (2 mg/kg) Rats ↓in AUC; ↑in Ka [36]
3 Leaf of Heinsia crinata (200 mg/kg) CQ (15 mg/kg) Rats Extract ↓ bioavailability of CQ [37]
4 Aqueous leaf extract of Azadirachta indica CQ (Dose not specified) Rabbit Extract ↑ & ↓ in pharmacokinetic parameters [38]
5 MAMA herbal antimalarial decoction (120 mg/kg) AQ (10 mg/kg) Mice Decoction ↑ the activity of AQ and its metabolites [39]
6 Ethanolic leaf extract of Lasianthera Africana (200 mg/kg) CQ (15 mg/kg) Rats. Extract ↑ & ↓ in pharmacokinetic parameters [40]
7 Ethanolic leaf extract of Vernonia amygdalina CQ (10 mg/kg) Rats Extract ↑ & ↓ in pharmacokinetic parameters [41]
8 Grapefruit juice (4 ml/kg) CQ (100 mg/kg) Mice ↑ plasma concentration of CQ [42]
9 Gnetum africana (200 mg/kg) CQ (15 mg/kg) Rats ↑ & ↓ in some pharmacokinetic parameters [24]
  1. Vernonia amygdalina (VA); Artesunate (ART); Plasmodium berghei (P. berghei); Chloroquine (CQ). Amodiaquine (AQ). ↓ (Decreased activity), ↑ (Increased activity)