International Journal of Phytomedicine and Phytotherapy
Table 3 Summary of studies on herbal-antimalarial drug interactions in normal animals (mice, rats and rabbits)
From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs
S/no | Medicinal plant | Conventional antimalarial drug | Animal | Interaction effect | Reference |
|---|---|---|---|---|---|
1 | Aqueous root extract of Cryptolepis sanguinolenta (36 g/kg) | ART (150 mg/kg) | Rats | Cryptolepis sanguinolenta decreases the effectiveness of ART | [35] |
2 | VA (250 and 500 mg/kg) | Dihydroartemisinin (2 mg/kg) | Rats | ↓in AUC; ↑in Ka | [36] |
3 | Leaf of Heinsia crinata (200 mg/kg) | CQ (15 mg/kg) | Rats | Extract ↓ bioavailability of CQ | [37] |
4 | Aqueous leaf extract of Azadirachta indica | CQ (Dose not specified) | Rabbit | Extract ↑ & ↓ in pharmacokinetic parameters | [38] |
5 | MAMA herbal antimalarial decoction (120 mg/kg) | AQ (10 mg/kg) | Mice | Decoction ↑ the activity of AQ and its metabolites | [39] |
6 | Ethanolic leaf extract of Lasianthera Africana (200 mg/kg) | CQ (15 mg/kg) | Rats. | Extract ↑ & ↓ in pharmacokinetic parameters | [40] |
7 | Ethanolic leaf extract of Vernonia amygdalina | CQ (10 mg/kg) | Rats | Extract ↑ & ↓ in pharmacokinetic parameters | [41] |
8 | Grapefruit juice (4 ml/kg) | CQ (100 mg/kg) | Mice | ↑ plasma concentration of CQ | [42] |
9 | Gnetum africana (200 mg/kg) | CQ (15 mg/kg) | Rats | ↑ & ↓ in some pharmacokinetic parameters | [24] |