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International Journal of Phytomedicine and Phytotherapy

Table 4 Summary of studies on herbal-antimalarial drugs interactions in human volunteers and in-vitro studies

From: Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

S/no Medicinal plant Conventional antimalarial drug Interaction effect Reference
1 Garcinia kola seed (12.5 g) Quinine sulphate (600 mg/kg) ↓ in peak plasma concentration of quinine and its metabolites [43]
2 Kola nut (12.5 g) Halofantrine (500 mg) ↓ in plasma concentrations of halofantrine and its active metabolite [44]
3 Garcinia kola seed Quinine: HPLC quantitative study Quinine was adsorbed on G. kola (indicating antagonism) [19]
  1. Vernonia amygdalina (VA); Artesunate (ART); Plasmodium berghei (P. berghei); Chloroquine (CQ). Amodiaquine (AQ). ↓ (Decrease activity)