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International Journal of Phytomedicine and Phytotherapy

Table 5 Effects of prolonged oral administration of extracts of four ethnomedicinal plants in rats on kidney function assay

From: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Group Type of toxicity study Urea (mmol/L) Creatinine Na+ (mmol/L) K+ (mmol/L)
Anogeissus leiocarpus Acute 5±0.23a 22.43±0.59a,x 135.2±0.60 4.47±0.09x
Sub-acute 4.27±0.19b,x 13.71±0.15b,x 133.7±0.52x 4.66±0.10x
Sub-chronic 5.29±0.22a,y 56.76±0.63a,y 136.9±0.28a,y 5.167±0.15a
Chronic 5.71±0.10a,y 57.11±0.65a,y 137±0.18a,y 5.367±0.22a,y
Azadirachta indica Acute 3.94±0.32 14.61±0.21 134.9±0.07 4.34±0.13
Sub-acute 4.04±0.18 14.24±0.41 134.8±0.43 4.407±0.31
Sub-chronic 4.03±0.26 14.37±0.25 134.7±0.15 4.349±0.13
Chronic 3.99±0.23 14.14±0.54 134.8±0.28 4.347±0.1
Tamarindus indica Acute 3.88±0.20 15.47±0.85 139.11±0.42 4.22±0.15
Sub-acute 3.62±0.27 13.68±0.42 136.49±0.15 5.07±0.20
Sub-chronic 4.09±0.21 14.91±0.33 136.14±0.27 4.96±0.06
Chronic 4.45±0.33 14.23±0.35 133.75±0.35 4.64±0.21
Khaya senegalensis Acute 4.65±0.10a 15.32±0.07a 135.3±0.24 4.7±0.07x
Sub-acute 4.37±0.12a,x 15.18±0.16a 134.9±0.52x 4.72±0.18x
Sub-chronic 4.63±0.05a,y 15.55±0.13a 135.9±0.09 5.52±0.12a,y
Chronic 4.74±0.06a,y 15.58±0.09a 136.3±0.17a,y 5.89±0.12a,y
  Distilled water 3.93±0.05b 14.17±0.22b 134.8±0.24b 4.29±0.16b
  1. a and b = significant difference between each group and control (distilled water) group; while x and y = significant different within each group