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International Journal of Phytomedicine and Phytotherapy

Table 5 Effects of prolonged oral administration of extracts of four ethnomedicinal plants in rats on kidney function assay

From: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Group

Type of toxicity study

Urea (mmol/L)

Creatinine

Na+ (mmol/L)

K+ (mmol/L)

Anogeissus leiocarpus

Acute

5±0.23a

22.43±0.59a,x

135.2±0.60

4.47±0.09x

Sub-acute

4.27±0.19b,x

13.71±0.15b,x

133.7±0.52x

4.66±0.10x

Sub-chronic

5.29±0.22a,y

56.76±0.63a,y

136.9±0.28a,y

5.167±0.15a

Chronic

5.71±0.10a,y

57.11±0.65a,y

137±0.18a,y

5.367±0.22a,y

Azadirachta indica

Acute

3.94±0.32

14.61±0.21

134.9±0.07

4.34±0.13

Sub-acute

4.04±0.18

14.24±0.41

134.8±0.43

4.407±0.31

Sub-chronic

4.03±0.26

14.37±0.25

134.7±0.15

4.349±0.13

Chronic

3.99±0.23

14.14±0.54

134.8±0.28

4.347±0.1

Tamarindus indica

Acute

3.88±0.20

15.47±0.85

139.11±0.42

4.22±0.15

Sub-acute

3.62±0.27

13.68±0.42

136.49±0.15

5.07±0.20

Sub-chronic

4.09±0.21

14.91±0.33

136.14±0.27

4.96±0.06

Chronic

4.45±0.33

14.23±0.35

133.75±0.35

4.64±0.21

Khaya senegalensis

Acute

4.65±0.10a

15.32±0.07a

135.3±0.24

4.7±0.07x

Sub-acute

4.37±0.12a,x

15.18±0.16a

134.9±0.52x

4.72±0.18x

Sub-chronic

4.63±0.05a,y

15.55±0.13a

135.9±0.09

5.52±0.12a,y

Chronic

4.74±0.06a,y

15.58±0.09a

136.3±0.17a,y

5.89±0.12a,y

 

Distilled water

3.93±0.05b

14.17±0.22b

134.8±0.24b

4.29±0.16b

  1. a and b = significant difference between each group and control (distilled water) group; while x and y = significant different within each group