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International Journal of Phytomedicine and Phytotherapy

Table 6 Effects of prolonged oral administration of extracts of four ethnomedicinal in rats on blood parameters

From: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Type of toxicity study

AL

AI

TI

KS

DW

Packed cell volume (%)

 Acute

41.67±2.03

39.00±5.51

33.33±2.60

44.33±3.48

41.67±4.41

 Sub-acute

40.67±0.33

37.33±2.40

39.67±3.38

44.67±7.13

40.67±3.71

 Sub-chronic

31.00±0.208

41.33±2.91

40.00±1.00

47.67±6.84

38.67±2.40

 Chronic

32.00±0.346

39.67±2.03

40.67±1.76

40.67±1.76

39.33±2.91

Haemoglobin

 Acute

13.67±0.88

13.10±1.73

12.10±0.59

14.53±1.35

13.37±1.77

 Sub-acute

13.03±0.26

12.53±0.87

13.53±0.79

13.10±2.62

11.07±0.52

 Sub-chronic

10.33±0.88

13.10±1.10

12.40±1.20

16.10±2.05a*

11.43±0.98b

 Chronic

9.33±0.67

11.10±0.59

12.10±0.67

11.67±0.33

11.97±1.00

Total red blood cell count (× 109L)

 Acute

7.23±0.15

7.93±0.58

7.17±0.44

7.60±0.57

7.37±0.71

 Sub-acute

7.43±0.28

6.63±0.86

7.37±0.35

7.60±0.90

7.80±0.42b

 Sub-chronic

7.60±0.40

7.20±0.57

6.93±0.07

8.50±0.75

7.60±0.50

 Chronic

7.23±0.50

8.40±0.64

7.60±0.50

9.07±1.02

8.10±0.78

Total white blood cell count

 Acute

10.53±1.01

13.03±0.55

7.40±0.92

11.60±0.87

9.23±1.42

 Sub-acute

9.60±0.70

7.37±1.17

10.43±0.64

9.97±1.76

10.40±0.72

 Sub-chronic

7.13±2.23

6.97±2.12

7.63±2.06

7.57±1.72

4.97±0.67b

 Chronic

5.97±1.60

8.20±1.67

6.57±2.23

8.33±1.29

10.17±1.77

Neutrophil (%)

 Acute

19.67±1.20

29.00±2.65

34.33±2.96

26.00±7.02

33.00±3.51

 Sub-acute

23.00±1.73

38.00±3.79

30.33±2.03

26.33±4.26

33.67±3.18

 Sub-chronic

30.67±2.33

29.33±3.28

18.33±2.91

38.00±4.73

32.33±1.20

 Chronic

31.00±1.00

39.00±0.00

36.00±3.79

22.00±2.08

33.67±2.91

Lymphocyte (%)

 Acute

66.67±6.57

67.67±4.26

55.67±4.06

65.00±5.57

53.67±5.90

 Sub-acute

65.67±4.26

52.00±4.73

48.67±8.74

53.00±6.56

49.33±5.93

 Sub-chronic

55.33±6.77

52.67±4.63

70.33±9.53

58.67±4.60

55.67±6.67

 Chronic

60.33±5.93

60.33±0.33

59.33±5.78

54.67±3.18

62.00±1.53

Monocyte (%)

 Acute

6.00±1.15

2.00±1.15

5.33±1.20

2.33±0.33

5.67±1.86

 Sub-acute

5.33±3.53

0.00±0.00

1.33±1.33

5.33±1.33

2.00±1.15

 Sub-chronic

2.33±1.86

7.33±2.40

4.00±2.00

1.33±0.88

5.00±2.08

 Chronic

5.33±2.19

0.33±0.33

3.33±2.33

6.67±0.67

3.67±2.19

Eosinophil (%)

 Acute

0.33±0.33

0.00±0.00

0.00±0.00

0.00±0.00

0.00±0.00

 Sub-acute

1.33±1.33

2.00±2.00

0.00±0.00

0.67±0.67

0.00±0.00

 Sub-chronic

0.00±0.00

2.33±1.20

0.33±0.33

1.00±0.58

0.00±0.00

 Chronic

1.33±1.33

1.67±1.20

0.00±0.00

2.33±2.33

0.00±0.00

Band neutrophil (%)

 Acute

0.33±0.33

0.67±0.67

1.00±0.58

0.67±0.67

1.00±0.58

 Sub-acute

0.33±0.33

0.33±0.33

0.67±0.67

4.67±3.71

1.00±0.58

 Sub-chronic

1.33±1.33

0.67±.33

0.00±0.00

1.00±0.58

0.33±0.33

 Chronic

0.67±0.67

0.33±0.33

1.33±1.33

1.33±0.33

0.67±0.67

  1. AL Anogeissus leiocarpus, AI Azadirachta indica, TI Tamarindus indica, KS Khaya senegalensis, DW Distilled water. Superscripts: a and b indicate significant difference; P < 0.05* and P< 0.001**