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International Journal of Phytomedicine and Phytotherapy

Table 6 Effects of prolonged oral administration of extracts of four ethnomedicinal in rats on blood parameters

From: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

Type of toxicity study AL AI TI KS DW
Packed cell volume (%)
 Acute 41.67±2.03 39.00±5.51 33.33±2.60 44.33±3.48 41.67±4.41
 Sub-acute 40.67±0.33 37.33±2.40 39.67±3.38 44.67±7.13 40.67±3.71
 Sub-chronic 31.00±0.208 41.33±2.91 40.00±1.00 47.67±6.84 38.67±2.40
 Chronic 32.00±0.346 39.67±2.03 40.67±1.76 40.67±1.76 39.33±2.91
Haemoglobin
 Acute 13.67±0.88 13.10±1.73 12.10±0.59 14.53±1.35 13.37±1.77
 Sub-acute 13.03±0.26 12.53±0.87 13.53±0.79 13.10±2.62 11.07±0.52
 Sub-chronic 10.33±0.88 13.10±1.10 12.40±1.20 16.10±2.05a* 11.43±0.98b
 Chronic 9.33±0.67 11.10±0.59 12.10±0.67 11.67±0.33 11.97±1.00
Total red blood cell count (× 109L)
 Acute 7.23±0.15 7.93±0.58 7.17±0.44 7.60±0.57 7.37±0.71
 Sub-acute 7.43±0.28 6.63±0.86 7.37±0.35 7.60±0.90 7.80±0.42b
 Sub-chronic 7.60±0.40 7.20±0.57 6.93±0.07 8.50±0.75 7.60±0.50
 Chronic 7.23±0.50 8.40±0.64 7.60±0.50 9.07±1.02 8.10±0.78
Total white blood cell count
 Acute 10.53±1.01 13.03±0.55 7.40±0.92 11.60±0.87 9.23±1.42
 Sub-acute 9.60±0.70 7.37±1.17 10.43±0.64 9.97±1.76 10.40±0.72
 Sub-chronic 7.13±2.23 6.97±2.12 7.63±2.06 7.57±1.72 4.97±0.67b
 Chronic 5.97±1.60 8.20±1.67 6.57±2.23 8.33±1.29 10.17±1.77
Neutrophil (%)
 Acute 19.67±1.20 29.00±2.65 34.33±2.96 26.00±7.02 33.00±3.51
 Sub-acute 23.00±1.73 38.00±3.79 30.33±2.03 26.33±4.26 33.67±3.18
 Sub-chronic 30.67±2.33 29.33±3.28 18.33±2.91 38.00±4.73 32.33±1.20
 Chronic 31.00±1.00 39.00±0.00 36.00±3.79 22.00±2.08 33.67±2.91
Lymphocyte (%)
 Acute 66.67±6.57 67.67±4.26 55.67±4.06 65.00±5.57 53.67±5.90
 Sub-acute 65.67±4.26 52.00±4.73 48.67±8.74 53.00±6.56 49.33±5.93
 Sub-chronic 55.33±6.77 52.67±4.63 70.33±9.53 58.67±4.60 55.67±6.67
 Chronic 60.33±5.93 60.33±0.33 59.33±5.78 54.67±3.18 62.00±1.53
Monocyte (%)
 Acute 6.00±1.15 2.00±1.15 5.33±1.20 2.33±0.33 5.67±1.86
 Sub-acute 5.33±3.53 0.00±0.00 1.33±1.33 5.33±1.33 2.00±1.15
 Sub-chronic 2.33±1.86 7.33±2.40 4.00±2.00 1.33±0.88 5.00±2.08
 Chronic 5.33±2.19 0.33±0.33 3.33±2.33 6.67±0.67 3.67±2.19
Eosinophil (%)
 Acute 0.33±0.33 0.00±0.00 0.00±0.00 0.00±0.00 0.00±0.00
 Sub-acute 1.33±1.33 2.00±2.00 0.00±0.00 0.67±0.67 0.00±0.00
 Sub-chronic 0.00±0.00 2.33±1.20 0.33±0.33 1.00±0.58 0.00±0.00
 Chronic 1.33±1.33 1.67±1.20 0.00±0.00 2.33±2.33 0.00±0.00
Band neutrophil (%)
 Acute 0.33±0.33 0.67±0.67 1.00±0.58 0.67±0.67 1.00±0.58
 Sub-acute 0.33±0.33 0.33±0.33 0.67±0.67 4.67±3.71 1.00±0.58
 Sub-chronic 1.33±1.33 0.67±.33 0.00±0.00 1.00±0.58 0.33±0.33
 Chronic 0.67±0.67 0.33±0.33 1.33±1.33 1.33±0.33 0.67±0.67
  1. AL Anogeissus leiocarpus, AI Azadirachta indica, TI Tamarindus indica, KS Khaya senegalensis, DW Distilled water. Superscripts: a and b indicate significant difference; P < 0.05* and P< 0.001**