International Journal of Phytomedicine and Phytotherapy
From: Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide
Herb | Country | Gender | Age (yeas) | Reason | Preparation | Renal side effect | Causality | Reference |
---|---|---|---|---|---|---|---|---|
Dioscorea quinqueloba | Korea | male | 52 | cardiovascular disease | Raw extract | biopsy-proven acute interstitial nephritis | Certain | 2014, [14] |
Dioscorea quinqueloba | Korea | male | 51 | for his own health | dug up tubers of D. quinqueloba and drank about 400 mL of juice made from the raw tubers | acute kidney injury | Probable | 2015, [15] |
Dioscorea quinqueloba | Korea | male | 68–58 | Diabetes mellitus and health tonics | extract from tubers | acute kidney injury | Possible | 2011, [16] |
Cape aloes | Soweto, South Africa | male | 47 | to clean his stomach | Taken the remedy by mouth at least three times during the month before admission, with the last dose about 10 days before admission. | acute oliguric renal failure and liver dysfunction | Certain | 2002, [17] |
Glycyrrhiza glabra | Serbia | female | 39 | sterility | ingestion of 50–100 g herbal products which contained licorice, every day for 8 weeks | Acute Renal Failure | Probable | 2010, [18] |
Unknown herbal vaginal pessary | Nigeria | female | 22 | To terminate an unwanted pregnancy | insertion of a locally prepared herb (semi-solid) into her genital tract | oliguric acute kidney injury | Probable | 2017, [19] |
Chenopodium polyspermum | Anatolia region, Turkey | male | 45 | to regulate his blood glucose levels | chronic renal failure | Possible | 2012, [20] | |
Nigella sativa | Turkey | female | 62 | antioxidant or antidiabetic effects | N. sativa tablets for 6 d at approximately 2000 to 2500 mg/d. | acute renal failure | Possible | 2013, [21] |
Tribulus terrestris Avena sativa Panax ginseng Zingiber officinale | Turkey | female | 50 | cardio-protective | 4 different combination herbal medicinal products twice a day for 2 weeks | Acute kidney injury | Possible | 2014, [22] |
African mango (Irvingia gabonensis) | Turkey | female | 42 | slimming purposes | Three months previously she started using 2 × 500 mg African mango | rapid renal progression | Probable | 2015, [23] |
Lawsonia inermis | Myanmar | male | 34 | swelling of his face and unhealthy appearance of his skin. | boiled henna leaves, of which he drank about 700 mL/ day for 3 days | acute kidney injury | Probable | 2017, [24] |
Lawsonia inermis L. | Kingdom of Saudi Arabia | male | 32 | chronic bloating and constipation | ingestion of large amounts of boiled henna | acute renal failure | Probable | 2013, [25] |
Artemisia herba-alba | Tunisia (North Africa) | male | 59 | antidiabetic agent | aqueous extract (two cups a day for two consecutive days) | acute tubular necrosis | Possible | 2010, [26] |
Euphorbia paralias | Tunisia | male | 29 | edema | one time ingestion of boiled plant of Euphorbia paralias ten days before | acute renal failure | Possible | 2013, [27] |
Cassia senna L. | Belgium | female | 52 | constipation | had ingested, for > 3 years, one liter of an herbal tea each day made from a bag containing 70 g of dry senna fruits | acute hepatic failure and renal impairment | Possible | 2005, [28] |
ayurvedic powder | India | male | 33 | eczematous skin lesions | Ingesttion of ayurvedic contained arsenic for last 6 months | acute kidney injury | Possible | 2011, [29] |
ayurvedic medication | India | female | 44 | to reduce the side effects of chemotherapy | Contained high levels of several heavy metals including those of mercury, lead, and manganese | acute renal failure | Possible | 2015, [30] |
ayurvedic supplement | India | male | 24 | fever and abdominal pain | Ingestion of Alternative Medicine Containing Lead | acute kidney injury | Possible | 2019, [31] |
Carica papaya | India | male | 62 | increase the platelet count | juice extracted from papaya leaves | acute kidney injury | Possible | 2019, [32] |
Tribulus terrestris | Iran | male | 28 | to prevent kidney stone formation | 2 L of T. terrestris water in two consecutive days | nephrotoxicity | Probable | 2010, [33] |
Aristolochia manshuriensis | chine | male | 41 | urinary tract infection | 4 boxes (each containing 40 small packets) of an herbal preparation called “Fen Qing Wu Lin Wan”. That was taken twice daily for twenty consecutive days. | died in renal failure | Certain | 2010, [34] |
Trigonella foenum-graecum | Iran | female | 62 | daily ingestion of heat extract of fenugreek | acute interstitial nephritis | Possible | 2017, [35] | |
Crataegus orientalis | Turkey | male | 68 | eating ½ kg of raw and drinking five cups of tea made from leaves 3 days before | Acute renal failure | Possible | 2008, [36] | |
Tripterygium wilfordii HookF | Southwest china | male | 36.6 | ingesting approximately 50 g of wild honey | 3 patients were at different degrees of renal damage, and 1 patient with severe symptoms died of acute renal failure 1 day after admission | Not excluded | 2016, [37] | |
Colchicum autumnale | Croatia | male | 62 | ate a salad of plant with green leaves regarded as wild garlic | nephrotoxic acute tubular necrosis | Possible | 2004, [38] | |
Rheum rhaponticum | Germany | female | 52 | increased ingestion of approximately 500 mg of rhubarb (fresh weight) per day in the last 4 weeks | acute renal failure | Possible | 2012, [39] | |
Pithecellobium jeringa | Malaysia | male | 45 | acute renal failure | Not excluded | 2007, [40] |