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International Journal of Phytomedicine and Phytotherapy

Table 1 Selected phytocompounds of therapeutic importance against head and neck cancer

From: Phytodentistry in Africa: prospects for head and neck cancers

Phytocompound Mechanism of action reference
Vinca alkaloids Disrupts microtubule function through tubulin interaction and destruction resulting
Stalls cell division and facilitate apoptosis
Berberine cancer cell death by simultaneous induction of autophagy and apoptosis
caused an increase in Bax expression and a decrease in mitochondrial membrane permeability, leading to mitochondrial apoptosis
Taxanes Interferes with the microtubules and cell division
Blocks epidermal growth factor receptor (EGFR)
[41, 42]
Curcumin Potent inhibitor of cell proliferation and inducer of programmed cell death in SCCHN by downregulating IκBα kinase (IKK) mediated NF-Kβ activation [59, 60]
Grape seeds proanthocyanidins (GSPs) Has the ability to hinder the SCCHN cell invasion by targeting the EGFR expression, as well as halting the transition from epithelial to mesenchymal cells [61]
Licochalcone-A Significantly increased death of pharyngeal squamous carcinoma FaDu cells with activated apoptotic factors and PARP in a caspase-dependent manner and decreased anti-apoptotic factors [64,65,66]
Resveratrol Cause cancer cell death via mitotic catastrophe, apoptosis and autophagy [67]