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International Journal of Phytomedicine and Phytotherapy

Table 1 Selected phytocompounds of therapeutic importance against head and neck cancer

From: Phytodentistry in Africa: prospects for head and neck cancers

Phytocompound Mechanism of action reference
Vinca alkaloids Disrupts microtubule function through tubulin interaction and destruction resulting
Stalls cell division and facilitate apoptosis
[42]
[43]
Berberine cancer cell death by simultaneous induction of autophagy and apoptosis
caused an increase in Bax expression and a decrease in mitochondrial membrane permeability, leading to mitochondrial apoptosis
[49]
Taxanes Interferes with the microtubules and cell division
Blocks epidermal growth factor receptor (EGFR)
[41, 42]
[57]
Curcumin Potent inhibitor of cell proliferation and inducer of programmed cell death in SCCHN by downregulating IκBα kinase (IKK) mediated NF-Kβ activation [59, 60]
Grape seeds proanthocyanidins (GSPs) Has the ability to hinder the SCCHN cell invasion by targeting the EGFR expression, as well as halting the transition from epithelial to mesenchymal cells [61]
Licochalcone-A Significantly increased death of pharyngeal squamous carcinoma FaDu cells with activated apoptotic factors and PARP in a caspase-dependent manner and decreased anti-apoptotic factors [64,65,66]
Resveratrol Cause cancer cell death via mitotic catastrophe, apoptosis and autophagy [67]