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International Journal of Phytomedicine and Phytotherapy

Table 1 Effect of n-hexane, chloroform and methanol soluble fractions of Sargassum ilicifolium on liver enzymes and bilirubin in normal and acetaminophen (AAP) dosed rats

From: Hepatoprotective activity against acetaminophen-induced liver dysfunction and GC-MS profiling of a brown algae Sargassum ilicifolium

Rat groups Normal rats AAP dosed rats Normal rats AAP dosed rats Normal
rats
AAP dosed rats Normal
rats
AAP dosed rats Normal rats AAP dosed rats
  ALT (U/L) AST (U/L) ALP (U/L) LDH (U/L) Bilirubin (mg/dl)
Control 33.6ab ± 3.5 104.6 a ± 9.4 134.3c ± 6 239.3b ± 8.1 67.6a ± 6.5 113.6a ± 10.4 328.6a ± 10 396.3a ± 6 0.4a ± 0 0.86a ± 0.06
hexane fraction of S. ilicifolium 30.3b ± 2.3 (−9.8%) 63b ± 2.6   (− 39.7%) 166.3b ± 8.6 (+ 23.8%) 178.3c ± 9.6 (−25.4%) 74a ± 3   (+ 9.4%) 87.3b ± 2.1 (− 23.1%) 312.6b ± 4.5 (− 4.8%) 303.3b ± 22  (− 23.4%) 0.46a ± 0.1 (+ 15%) 0.6b ± 0.1   (− 30.2%)
Chloroform fraction of S. ilicifolium 38.3a ± 3.5 (+ 13.9%) 99.6a ± 17 (− 4.7%) 237.6a ± 19.4 (+ 76.9%) 295.3a ± 8  (+ 23.4%) 67.6a ± 3.5 (0) 106.6a ± 6.5 (− 6.16%) 298b ± 7    (− 9.3%) 303b ± 8      (− 23.5%) 0.43a ± 0.05 (+ 7.5%) 0.66b ± 0.06 (− 23.2%)
Methanol fraction of S. ilicifolium 35.6ab ± 3.2 (+ 5.9%) 66.6b ± 2.5 (− 36.3%) 180.3b ± 4.5 (+ 34.2%) 182.3c ± 13 (− 23.8%) 71a ± 2.6 (+ 5.0%) 79.6b ± 2    (− 29.9%) 312.6b ± 9 (− 4.86%) 331.3b ± 19.6 (− 16.4%) 0.46a ± 0   (+ 15%) 0.53b ± 0.06 (− 38.3%)
  1. The values were expressed as means ± Standard error (n = 6). The values having the same superscript within the column are not significantly (p < 0.05) different according to Duncan’s multiple range test. Values in parenthesis are showing percent increased or decreased as compared to their respective control