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International Journal of Phytomedicine and Phytotherapy

Table 3 Effect of silymarin at dose of 50 mg/kg b.w., on liver enzymes and bilirubin in normal and acetaminophen (AAP) dosed rats

From: Hepatoprotective activity against acetaminophen-induced liver dysfunction and GC-MS profiling of a brown algae Sargassum ilicifolium

Rat groups ALT (U/L) AST (U/L) ALP (U/L) LDH (U/L) Bilirubin (mg/dl)
Normal control 35.6b ± 2.08 94.6c ± 6.8 53c ± 7 216.3c ± 13.05 0.56c ± 0.057
Silymarin (50 mg/kg b.w.) 34.3b ± 3.5a (− 3.6%) 91.6c ± 14.5a (− 3.1%) 43.6c ± 4.7a (− 17.7%) 176.3d ± 20.1a (− 18.4%) 0.46c ± 0.115a (− 17.8%)
Acetaminophen 91.3a ± 10.9a (+ 156.4%) 214.6a ± 20.5a (+ 126.8%) 112a ± 13.5a (+ 111.3%) 374a ± 11.1a (+ 72.9%) 0.9a ± 0.1a (+ 60.7%)
Silymarin (50 mg/ kg b.w.) Acetaminophen 44.3b ± 6.8b (− 51.4%) 120.6b ± 8.3b (− 43.8%) 79b ± 5.2b (− 29.4%) 250.6b ± 10.2b (− 32.9%) 0.73b ± 0.057b (− 18.8%)
  1. The values were expressed as means ± standard error (n = 6)
  2. a Compared with normal control,
  3. b Compared with acetaminophen control
  4. Values in parenthesis are showing percent increased or decreased as compared to their respective control
  5. The values having the same superscript within the column are not significantly (p < 0.05) different according to Duncan’s multiple range test