Table 3 Effect of silymarin at dose of 50 mg/kg b.w., on liver enzymes and bilirubin in normal and acetaminophen (AAP) dosed rats

Normal control

35.6^b ± 2.08

94.6^c ± 6.8

53^c ± 7

216.3^c ± 13.05

0.56^c ± 0.057

Silymarin (50 mg/kg b.w.)

34.3^b ± 3.5^a (− 3.6%)

91.6^c ± 14.5^a (− 3.1%)

43.6^c ± 4.7^a (− 17.7%)

176.3^d ± 20.1^a (− 18.4%)

0.46^c ± 0.115^a (− 17.8%)

Acetaminophen

91.3^a ± 10.9^a (+ 156.4%)

214.6^a ± 20.5^a (+ 126.8%)

112^a ± 13.5^a (+ 111.3%)

374^a ± 11.1^a (+ 72.9%)

0.9^a ± 0.1^a (+ 60.7%)

Silymarin (50 mg/ kg b.w.) Acetaminophen

44.3^b ± 6.8^b (− 51.4%)

120.6^b ± 8.3^b (− 43.8%)

79^b ± 5.2^b (− 29.4%)

250.6^b ± 10.2^b (− 32.9%)

0.73^b ± 0.057^b (− 18.8%)