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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of XNE on haematological parameters in male and female rats during the 90-day safety assessments

From: Safety assessment of the standardized aqueous extract from solid-state cultured Xylaria nigripes (Wuling Shen) in rats

Parameters Control Low Medium High
Male
 WBC (103/μL) 12.38 ± 3.16 12.65 ± 4.86 14.01 ± 3.77 12.22 ± 3.05
 RBC (106/μL) 10.41 ± 0.58 10.10 ± 0.69 9.81 ± 0.67 10.18 ± 0.57
 Haemoglobin (g/dL) 17.84 ± 1.05 17.35 ± 0.84 17.17 ± 1.09 17.64 ± 0.73
 Hematocrit (%) 61.50 ± 3.51 59.62 ± 3.22 58.08 ± 3.76 60.30 ± 3.78
 MCV (fL) 59.14 ± 2.41 59.09 ± 1.55 59.23 ± 1.47 59.23 ± 1.14
 MCH (pg) 17.16 ± 0.88 17.20 ± 0.50 17.52 ± 0.67 17.35 ± 0.47
 MCHC (g/dL) 29.00 ± 0.64 29.14 ± 0.85 29.57 ± 0.47 29.28 ± 0.81
 Platelet (μL) 1512 ± 259 1443 ± 257 1422 ± 143 1439 ± 243
 Neutrophils (%) 14.35 ± 4.14 12.36 ± 2.64 12.01 ± 4.21 13.04 ± 3.22
 Lymphocyte (%) 79.40 ± 7.19 81.98 ± 3.74 83.03 ± 5.99 80.98 ± 4.88
 Monocyte (%) 5.10 ± 3.42 4.36 ± 3.21 3.63 ± 3.18 4.95 ± 3.81
 Eosinophil (%) 0.98 ± 0.35 1.05 ± 0.45 1.14 ± 0.20 0.80 ± 0.36
 Basophil (%) 0.16 ± 0.07 0.25 ± 0.21 0.19 ± 0.13 0.23 ± 0.14
 PT (sec) 11.15 ± 1.76 10.59 ± 0.78 10.82 ± 0.81 11.20 ± 0.86
 APTT (sec) 42.38 ± 10.46 44.26 ± 6.34 40.33 ± 7.09 41.62 ± 4.90
Female
 WBC (103/μL) 7.91 ± 2.33 8.72 ± 2.49 11.08 ± 3.04 9.77 ± 2.06
 RBC (106/μL) 9.31 ± 0.51 8.60 ± 0.61 9.04 ± 0.53 8.91 ± 0.70
 Haemoglobin (g/dL) 16.92 ± 1.14 15.87 ± 0.86 16.56 ± 0.72 16.23 ± 1.16
 Hematocrit (%) 56.36 ± 3.66 52.41 ± 3.39 54.14 ± 2.38 53.21 ± 4.17
 MCV (fL) 60.50 ± 1.89 60.97 ± 1.52 59.94 ± 2.07 59.74 ± 2.10
 MCH (pg) 18.17 ± 0.58 18.48 ± 0.71 18.34 ± 0.63 18.24 ± 0.55
 MCHC (g/dL) 30.02 ± 0.58 30.30 ± 0.64 30.59 ± 0.71 30.54 ± 0.57
 Platelet (μL) 1188 ± 249 1071 ± 395 1115 ± 182 1051 ± 300
 Neutrophils (%) 9.27 ± 2.50 9.68 ± 2.60 9.08 ± 3.07 8.58 ± 2.24
 Lymphocyte (%) 86.27 ± 5.38 85.26 ± 3.81 86.18 ± 5.69 87.03 ± 3.26
 Monocyte (%) 3.56 ± 3.78 4.25 ± 3.14 3.67 ± 3.52 3.39 ± 2.91
 Eosinophil (%) 0.76 ± 0.37 0.63 ± 0.29 0.89 ± 0.60 0.82 ± 0.67
 Basophil (%) 0.14 ± 0.10 0.18 ± 0.14 0.18 ± 0.10 0.18 ± 0.11
 PT (sec) 9.51 ± 0.27 9.38 ± 0.27 9.84 ± 0.60 10.11 ± 0.89
 APTT (sec) 42.19 ± 5.71 38.05 ± 8.42 37.61 ± 5.93 36.54 ± 3.58
  1. Key: Data are expressed as mean ± SD (n = 10). WBC White blood cells, RBC Red blood cells, MCV Mean corpuscular volume, MCH Mean corpuscular haemoglobin, MCHC Mean corpuscular haemoglobin concentration, PT Prothrombin time, APTT Activated partial thromboplastin time