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International Journal of Phytomedicine and Phytotherapy

Table 2 Effects of XNE on haematological parameters in male and female rats during the 90-day safety assessments

From: Safety assessment of the standardized aqueous extract from solid-state cultured Xylaria nigripes (Wuling Shen) in rats

Parameters

Control

Low

Medium

High

Male

 WBC (103/μL)

12.38 ± 3.16

12.65 ± 4.86

14.01 ± 3.77

12.22 ± 3.05

 RBC (106/μL)

10.41 ± 0.58

10.10 ± 0.69

9.81 ± 0.67

10.18 ± 0.57

 Haemoglobin (g/dL)

17.84 ± 1.05

17.35 ± 0.84

17.17 ± 1.09

17.64 ± 0.73

 Hematocrit (%)

61.50 ± 3.51

59.62 ± 3.22

58.08 ± 3.76

60.30 ± 3.78

 MCV (fL)

59.14 ± 2.41

59.09 ± 1.55

59.23 ± 1.47

59.23 ± 1.14

 MCH (pg)

17.16 ± 0.88

17.20 ± 0.50

17.52 ± 0.67

17.35 ± 0.47

 MCHC (g/dL)

29.00 ± 0.64

29.14 ± 0.85

29.57 ± 0.47

29.28 ± 0.81

 Platelet (μL)

1512 ± 259

1443 ± 257

1422 ± 143

1439 ± 243

 Neutrophils (%)

14.35 ± 4.14

12.36 ± 2.64

12.01 ± 4.21

13.04 ± 3.22

 Lymphocyte (%)

79.40 ± 7.19

81.98 ± 3.74

83.03 ± 5.99

80.98 ± 4.88

 Monocyte (%)

5.10 ± 3.42

4.36 ± 3.21

3.63 ± 3.18

4.95 ± 3.81

 Eosinophil (%)

0.98 ± 0.35

1.05 ± 0.45

1.14 ± 0.20

0.80 ± 0.36

 Basophil (%)

0.16 ± 0.07

0.25 ± 0.21

0.19 ± 0.13

0.23 ± 0.14

 PT (sec)

11.15 ± 1.76

10.59 ± 0.78

10.82 ± 0.81

11.20 ± 0.86

 APTT (sec)

42.38 ± 10.46

44.26 ± 6.34

40.33 ± 7.09

41.62 ± 4.90

Female

 WBC (103/μL)

7.91 ± 2.33

8.72 ± 2.49

11.08 ± 3.04

9.77 ± 2.06

 RBC (106/μL)

9.31 ± 0.51

8.60 ± 0.61

9.04 ± 0.53

8.91 ± 0.70

 Haemoglobin (g/dL)

16.92 ± 1.14

15.87 ± 0.86

16.56 ± 0.72

16.23 ± 1.16

 Hematocrit (%)

56.36 ± 3.66

52.41 ± 3.39

54.14 ± 2.38

53.21 ± 4.17

 MCV (fL)

60.50 ± 1.89

60.97 ± 1.52

59.94 ± 2.07

59.74 ± 2.10

 MCH (pg)

18.17 ± 0.58

18.48 ± 0.71

18.34 ± 0.63

18.24 ± 0.55

 MCHC (g/dL)

30.02 ± 0.58

30.30 ± 0.64

30.59 ± 0.71

30.54 ± 0.57

 Platelet (μL)

1188 ± 249

1071 ± 395

1115 ± 182

1051 ± 300

 Neutrophils (%)

9.27 ± 2.50

9.68 ± 2.60

9.08 ± 3.07

8.58 ± 2.24

 Lymphocyte (%)

86.27 ± 5.38

85.26 ± 3.81

86.18 ± 5.69

87.03 ± 3.26

 Monocyte (%)

3.56 ± 3.78

4.25 ± 3.14

3.67 ± 3.52

3.39 ± 2.91

 Eosinophil (%)

0.76 ± 0.37

0.63 ± 0.29

0.89 ± 0.60

0.82 ± 0.67

 Basophil (%)

0.14 ± 0.10

0.18 ± 0.14

0.18 ± 0.10

0.18 ± 0.11

 PT (sec)

9.51 ± 0.27

9.38 ± 0.27

9.84 ± 0.60

10.11 ± 0.89

 APTT (sec)

42.19 ± 5.71

38.05 ± 8.42

37.61 ± 5.93

36.54 ± 3.58

  1. Key: Data are expressed as mean ± SD (n = 10). WBC White blood cells, RBC Red blood cells, MCV Mean corpuscular volume, MCH Mean corpuscular haemoglobin, MCHC Mean corpuscular haemoglobin concentration, PT Prothrombin time, APTT Activated partial thromboplastin time