|
Groups
|
n
|
Biochemical parameters (on 13th day)
|
|---|
|
AChE activity (U/g)
|
Cholesterol (mg/dl)
|
Glucose (U/g)
|
MDA (µmol/g of tissue)
|
GSH (µmol/g of tissue)
|
|---|
|
Control (Normal saline)
|
6
|
16.9 ± 1.09
|
114 ± 2.17
|
132.06 ± 4.98
|
0.240 ± 0.016
|
1.47 ± 0.10
|
|
Piracetam (400 mg/kg, i.p.)
|
6
|
10.41 ± 0.61**
|
81.33 ± 2.90**
|
106.89 ± 4.03**
|
0.99 ± 0.01**
|
2.09 ± 0.079**
|
|
EEC (100 mg/kg, p.o.)
|
6
|
14.90 ± 0.69
|
102.42 ± 1.54*
|
124.46 ± 4.89
|
0.201 ± 0.009
|
1.96 ± 0.09**
|
|
EEC (300 mg/kg, p.o.)
|
6
|
13.58 ± 0.58
|
96.5 ± 1.48**
|
119.89 ± 4.03
|
0.192 ± 0.01
|
1.98 ± 0.03**
|
|
EEC (500 mg/kg, p.o.)
|
6
|
11.90 ± 0.73**
|
89.0 ± 4.12**
|
117.26 ± 4.25
|
0.172 ± 0.02*
|
2.12 ± 0.01**
|
|
Diazepam (1 mg/kg, i.p.)
|
6
|
29.72 ± 0.88**
|
118.3 ± 3.79
|
142.05 ± 5.08
|
0.244 ± 0.025
|
1.17 ± 0.02*
|
- All values are mean ± SEM (n = number of animals in each group). Data was analyzed using one-way ANOVA followed by Dunnett test. *** p < 0.001, ** p < 0.01 and * p < 0.05 vs. normal control group
- EEC: ethanolic extract of Elettaria cardamomum; AChE: acetylcholinesterase; MDA: malondialdehyde; GSH: glutathione
