Table 5 Comparison of the symptoms dynamics in the observation groups according to the self-assessment (Mann-Whitney U test)
From: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19
|
Indicator
|
Reference point
|
Mann–Whitney U test
|
Wilcoxon’s test W
|
Statistics Z
|
p-value
|
Differences significance*
|
|---|
|
Fever
|
Day 2–Day 1
|
1085.50
|
2310.50
|
-0.696
|
0.487
|
Non-significant
|
|
Day 3–Day 1
|
1001.50
|
2226.50
|
-1.276
|
0.202
|
Non-significant
|
|
Day 4–Day 1
|
812.00
|
2037.00
|
-2.584
|
0.010
|
Significant
|
|
Day 5–Day 1
|
806.00
|
2031.00
|
-2.594
|
0.009
|
Significant
|
|
Day 6–Day 1
|
774.00
|
1999.00
|
-2.807
|
0.005
|
Significant
|
|
Day 7–Day 1
|
824.50
|
2049.50
|
-2.434
|
0.015
|
Significant
|
|
Day 8–Day 1
|
868.50
|
2093.50
|
-2.103
|
0.035
|
Significant
|
|
Day 9–Day 1
|
892.00
|
2117.00
|
-1.928
|
0.054
|
Non-significant
|
|
Day 10–Day 1
|
978.50
|
2203.50
|
-1.288
|
0.198
|
Non-significant
|
|
Day 11–Day 1
|
994.00
|
2219.00
|
-1.172
|
0.241
|
Non-significant
|
|
Day 12–Day 1
|
1067.50
|
2292.50
|
-0.625
|
0.532
|
Non-significant
|
|
Day 13–Day 1
|
1095.50
|
2320.50
|
-0.417
|
0.677
|
Non-significant
|
|
Myalgia
|
Day 2–Day 1
|
1069.50
|
2294.50
|
-0.883
|
0.377
|
Non-significant
|
|
Day 3–Day 1
|
903.00
|
2128.00
|
-2.117
|
0.034
|
Significant
|
|
Day 4–Day 1
|
630.50
|
1855.50
|
-4.058
|
0.000
|
Significant
|
|
Day 5–Day 1
|
653.50
|
1878.50
|
-3.734
|
0.000
|
Significant
|
|
Day 6–Day 1
|
599.00
|
1824.00
|
-4.104
|
0.000
|
Significant
|
|
Day 7–Day 1
|
674.00
|
1899.00
|
-3.555
|
0.000
|
Significant
|
|
Day 8–Day 1
|
638.00
|
1863.00
|
-3.797
|
0.000
|
Significant
|
|
Day 9–Day 1
|
684.00
|
1909.00
|
-3.463
|
0.001
|
Significant
|
|
Day 10–Day 1
|
656.50
|
1881.50
|
-3.664
|
0.000
|
Significant
|
|
Day 11–Day 1
|
658.50
|
1883.50
|
-3.653
|
0.000
|
Significant
|
|
Day 12–Day 1
|
679.00
|
1904.00
|
-3.498
|
0.000
|
Significant
|
|
Day 13–Day 1
|
700.00
|
1925.00
|
-3.342
|
0.001
|
Significant
|
|
Nasal congestion
|
Day 2–Day 1
|
1130.00
|
2355.00
|
-0.227
|
0.821
|
Non-significant
|
|
Day 3–Day 1
|
867.00
|
2092.00
|
-2.465
|
0.014
|
Significant
|
|
Day 4–Day 1
|
720.50
|
1945.50
|
-3.400
|
0.001
|
Significant
|
|
Day 5–Day 1
|
669.50
|
1894.50
|
-3.637
|
0.000
|
Significant
|
|
Day 6–Day 1
|
596.50
|
1821.50
|
-4.160
|
0.000
|
Significant
|
|
Day 7–Day 1
|
608.50
|
1833.50
|
-4.055
|
0.000
|
Significant
|
|
Day 8–Day 1
|
616.00
|
1841.00
|
-3.979
|
0.000
|
Significant
|
|
Day 9–Day 1
|
629.50
|
1854.50
|
-3.877
|
0.000
|
Significant
|
|
Day 10–Day 1
|
643.00
|
1868.00
|
-3.781
|
0.000
|
Significant
|
|
Day 11–Day 1
|
691.50
|
1916.50
|
-3.415
|
0.001
|
Significant
|
|
Day 12–Day 1
|
720.00
|
1945.00
|
-3.200
|
0.001
|
Significant
|
|
Day 13–Day 1
|
725.50
|
1950.50
|
-3.155
|
0.002
|
Significant
|
|
Sore throat
|
Day 2–Day 1
|
911.00
|
2136.00
|
-2.536
|
0.011
|
Significant
|
|
Day 3–Day 1
|
834.00
|
2059.00
|
-2.679
|
0.007
|
Significant
|
|
Day 4–Day 1
|
866.00
|
2091.00
|
-2.267
|
0.023
|
Significant
|
|
Day 5–Day 1
|
995.50
|
2220.50
|
-1.211
|
0.226
|
Non-significant
|
|
Day 6–Day 1
|
970.50
|
2195.50
|
-1.397
|
0.162
|
Non-significant
|
|
Day 7–Day 1
|
1026.50
|
2251.50
|
-0.956
|
0.339
|
Non-significant
|
|
Day 8–Day 1
|
1034.50
|
2259.50
|
-0.893
|
0372
|
Non-significant
|
|
Day 9–Day 1
|
1038.50
|
2263.50
|
-0.858
|
0.391
|
Non-significant
|
|
Day 10–Day 1
|
1078.50
|
2303.50
|
-0.555
|
0.579
|
Non-significant
|
|
Day 11–Day 1
|
1069.00
|
2294.00
|
-0.628
|
0.530
|
Non-significant
|
|
Day 12–Day 1
|
1116.00
|
2341.00
|
-0.271
|
0.787
|
Non-significant
|
|
Day 13–Day 1
|
1100.00
|
2325.00
|
-0.391
|
0.696
|
Non-significant
|
- *The conclusion has been made at a significance level of 0.05
