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International Journal of Phytomedicine and Phytotherapy

Table 5 Comparison of the symptoms dynamics in the observation groups according to the self-assessment (Mann-Whitney U test)

From: A randomized, open-label, multicentre, comparative study of therapeutic efficacy, safety, and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb, in the treatment of mild forms of COVID-19

Indicator Reference point Mann–Whitney U test Wilcoxon’s test W Statistics Z p-value Differences significance*
Fever Day 2–Day 1 1085.50 2310.50 -0.696 0.487 Non-significant
Day 3–Day 1 1001.50 2226.50 -1.276 0.202 Non-significant
Day 4–Day 1 812.00 2037.00 -2.584 0.010 Significant
Day 5–Day 1 806.00 2031.00 -2.594 0.009 Significant
Day 6–Day 1 774.00 1999.00 -2.807 0.005 Significant
Day 7–Day 1 824.50 2049.50 -2.434 0.015 Significant
Day 8–Day 1 868.50 2093.50 -2.103 0.035 Significant
Day 9–Day 1 892.00 2117.00 -1.928 0.054 Non-significant
Day 10–Day 1 978.50 2203.50 -1.288 0.198 Non-significant
Day 11–Day 1 994.00 2219.00 -1.172 0.241 Non-significant
Day 12–Day 1 1067.50 2292.50 -0.625 0.532 Non-significant
Day 13–Day 1 1095.50 2320.50 -0.417 0.677 Non-significant
Myalgia Day 2–Day 1 1069.50 2294.50 -0.883 0.377 Non-significant
Day 3–Day 1 903.00 2128.00 -2.117 0.034 Significant
Day 4–Day 1 630.50 1855.50 -4.058 0.000 Significant
Day 5–Day 1 653.50 1878.50 -3.734 0.000 Significant
Day 6–Day 1 599.00 1824.00 -4.104 0.000 Significant
Day 7–Day 1 674.00 1899.00 -3.555 0.000 Significant
Day 8–Day 1 638.00 1863.00 -3.797 0.000 Significant
Day 9–Day 1 684.00 1909.00 -3.463 0.001 Significant
Day 10–Day 1 656.50 1881.50 -3.664 0.000 Significant
Day 11–Day 1 658.50 1883.50 -3.653 0.000 Significant
Day 12–Day 1 679.00 1904.00 -3.498 0.000 Significant
Day 13–Day 1 700.00 1925.00 -3.342 0.001 Significant
Nasal congestion Day 2–Day 1 1130.00 2355.00 -0.227 0.821 Non-significant
Day 3–Day 1 867.00 2092.00 -2.465 0.014 Significant
Day 4–Day 1 720.50 1945.50 -3.400 0.001 Significant
Day 5–Day 1 669.50 1894.50 -3.637 0.000 Significant
Day 6–Day 1 596.50 1821.50 -4.160 0.000 Significant
Day 7–Day 1 608.50 1833.50 -4.055 0.000 Significant
Day 8–Day 1 616.00 1841.00 -3.979 0.000 Significant
Day 9–Day 1 629.50 1854.50 -3.877 0.000 Significant
Day 10–Day 1 643.00 1868.00 -3.781 0.000 Significant
Day 11–Day 1 691.50 1916.50 -3.415 0.001 Significant
Day 12–Day 1 720.00 1945.00 -3.200 0.001 Significant
Day 13–Day 1 725.50 1950.50 -3.155 0.002 Significant
Sore throat Day 2–Day 1 911.00 2136.00 -2.536 0.011 Significant
Day 3–Day 1 834.00 2059.00 -2.679 0.007 Significant
Day 4–Day 1 866.00 2091.00 -2.267 0.023 Significant
Day 5–Day 1 995.50 2220.50 -1.211 0.226 Non-significant
Day 6–Day 1 970.50 2195.50 -1.397 0.162 Non-significant
Day 7–Day 1 1026.50 2251.50 -0.956 0.339 Non-significant
Day 8–Day 1 1034.50 2259.50 -0.893 0372 Non-significant
Day 9–Day 1 1038.50 2263.50 -0.858 0.391 Non-significant
Day 10–Day 1 1078.50 2303.50 -0.555 0.579 Non-significant
Day 11–Day 1 1069.00 2294.00 -0.628 0.530 Non-significant
Day 12–Day 1 1116.00 2341.00 -0.271 0.787 Non-significant
Day 13–Day 1 1100.00 2325.00 -0.391 0.696 Non-significant
  1. *The conclusion has been made at a significance level of 0.05