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International Journal of Phytomedicine and Phytotherapy

Table 7 Effect of AKSS16-LIV01 on haematological parameters in chronic ethanol-induced hepatic damage in mice

From: Antioxidant and immunomodulatory effect of AKSS16-LIV01 – a multi herbal formulation against ethanol induced liver dysfunction in mice

Parameters Normal Ethanol Ethanol + AKSS16-LIV01 (75) Ethanol+AKSS16-LIV01 (150) Ethanol+AKSS16-LIV01 (300) Ethanol +Silymarin(100) AKSS16-LIV01 (300)
Hb (g %) 12.1 ± 1.05 9.03 ± 0.89# 12.0 ± 1.02* 11.05 ± 0.99* 12.51 ± 0.95** 10.96 ± 0.74 11.21 ± 0.82
RBC (× 106 cm2) 10.8 ± 0.82 8.1 ± 0.71# 10.5 ± 0.77* 9.44 ± 0.71 10.02 ± 0.85* 9.85 ± 0.79 9.62 ± 0.84
RT (%) 2.7 ± 0.12 4.9 ± 0.26# 2.6 ± 0.14* 3.1 ± 0.14 2.8 ± 0.15* 3.0 ± 0.12* 3.6 ± 0.16
HCT (%) 34.6 ± 0.48 39.4 ± 0.55# 34.1 ± 0.44* 35.8 ± 0.51 34.9 ± 0.56* 34.4 ± 0.51* 35.1 ± 0.77
MCV (μm3) 37.8 ± 0.32 31.0 ± 0.68 36.7 ± 0.29* 36.5 ± 0.44 35.9 ± 0.79 36.2 ± 0.43* 35.5 ± 0.36
MCH (pg) 21.2 ± 0.15 22.2 ± 0.14# 22.8 ± 0.23* 21.1 ± 0.12* 21.4 ± 0.11* 21.2 ± 0.14 21.1 ± 0.12
MCHC (%) 41.2 ± 1.06 32.4 ± 0.95# 40.2 ± 1.07 37.1 ± 0.92 39.6 ± 0.87* 38.6 ± 0.99 36.2 ± 0.91
Platelets 6.5 ± 0.02 5.5 ± 0.03 6.5 ± 0.04 5.8 ± 0.05 6.1 ± 0.07 5.5 ± 0.05 5.4 ± 0.06
WBC (× 105 cm2)) 9.2 ± 0.09 12.4 ± 0.11# 9.1 ± 0.08 10.8 ± 0.12 9.2 ± 0.11** 10.1 ± 0.13 10.7 ± 0.11
Lymphocyte 74 ± 2.98 79 ± 3.04# 72 ± 2.54* 73 ± 3.06* 74 ± 2.58* 72 ± 3.08* 71 ± 3.11
Neutrophil 26 ± 1.12 15 ± 0.49# 24 ± 1.09* 20 ± 0.56* 25 ± 0.69** 24 ± 0.51* 21.52 ± 2.09
  1. Data are expressed as mean ± standard deviation (N = 6). Hb Haemoglobin, RBC Read Blood corpuscle, RT Reticulocyte, HCT Haematocrit, MCV Mean corpuscular volume, MCH Mean corpuscular haemoglobin, MCHC Mean corpuscular haemoglobin concentration, WBC White Blood corpuscle
  2. The values are expressed as the mean ± SEM. Significantly different from control #p < 0.001 and significantly different from ethanol*p < 0.05, **p < 0.001using analysis of variance (ANOVA) followed by Dunnettʼs Multiple Comparison Test