Safety assessment of bio-synthesized iodine-doped silver nanoparticle wound ointment in experimental rats

Clinical Phytoscience

International Journal of Phytomedicine and Phytotherapy

Table 1 Effects of 21-days treatment of wound with PEG, Ag-NPs and Ag-INPs on haematological parameters of albino rats

Parameters	Control	Standard	Untreated	PEG	Ag NP	Ag-I NP
Hb (g/L)	10.95 ± 1.35^bc	9.50 ± 0.00^b	11.75 ± 1.05^bc	13.35 ± 0.05^c	13.50 ± 0.60^c	4.95 ± 0.55^a
PCV (%)	35.00 ± 3.00^bc	30.00 ± 0.00^b	37.00 ± 3.00^bc	42.00 ± 2.00^c	41.50 ± 1.50^c	14.50 ± 1.50^a
MCV (fL)	56.00 ± 2.00^a	54.00 ± 1.00^a	56.00 ± 2.00^a	54.50 ± 2.50^a	51.00 ± 0.00^a	54.00 ± 0.00^a
MCH (Pg)	15.50 ± 0.50^b	17.00 ± 1.00^b	16.00 ± 0.00^b	17.00 ± 0.00^b	13.00 ± 3.00^ab	8.00 ± 2.00^a
MCHC(g/dL)	28.00 ± 2.00^b	31.00 ± 1.00^b	30.00 ± 0.00^b	31.50 ± 1.50^b	26.00 ± 6.00_b	13.50 ± 3.50^a
RBC (× 10¹²/L)	7.25 ± 1.25^ab	5.60 ± 0.30^a	7.35 ± 0.55^ab	7.75 ± 0.05^ab	11.05 ± 1.95^b	7.15 ± 2.45^ab
PLC(× 10⁹/L)	6.98 ± 0.00^a	5.35 ± 0.00^a	7.23 ± 0.00^a	8.23 ± 6.50^a	7.64 ± 3.40^a	1.27 ± 9.28^a
TWBC(× 10⁹/L)	3.10 ± 0.00^ab	5.25 ± 0.25^bc	5.10 ± 1.10^bc	5.60 ± 0.60^c	10.20 ± 0.90^d	2.65 ± 0.55^a
Neu (%)	9.00 ± 1.00^a	8.50 ± 0.50^a	7.50 ± 0.50^a	10.50 ± 0.50^a	10.50 ± 3.50^a	17.50 ± 12.50^a
Lym (%)	75.00 ± 1.00^a	72.00 ± 3.00^a	70.50 ± 2.50^a	75.50 ± 4.50^a	80.50 ± 3.50^a	52.00 ± 18.00^a
MEB (%)	16.00 ± 2.00^ab	19.50 ± 3.50^ab	22.00 ± 2.00^ab	14.00 ± 4.00^a	9.00 ± 7.00^a	30.50 ± 5.50^b
RDWC (%)	15.30 ± 0.40^a	15.85 ± 0.55^a	16.15 ± 0.25^ab	15.55 ± 0.85^a	18.90 ± 0.60^c	18.75 ± 1.35^bc

Biochemical analysis Values are expressed in mean ± standard error of mean. Values with the same superscript across the row have no significant different at p < 0.05
Hb Haemoglobin count, PCV packed cell volume, MCV mean cell volume, MCH Mean corpuscular haemoglobin, MCHC Mean corpuscular haemoglobin concentration, RBC red blood cells, PLCx10² platelet count, TWBC total white blood cells, Neu neutrophils, Lym lymphocytes, MEB monocytes, eosinophils, basophils and RDWC red cell distribution width