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International Journal of Phytomedicine and Phytotherapy

Fig. 3 | Clinical Phytoscience

Fig. 3

From: Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

Fig. 3

C-peptide and HbA1c levels on day 28. C-peptide levels indicate total or partial destruction of pancreatic β-cells in STZ- and NIA/STZ- rat groups, respectively, and that treatment with CCAE for 28 days did not increase insulin secretion remaining β-cells. HbA1C levels increased in diabetic groups; 28 days of treatment with CCAE did not produce any change in HbA1C levels of treated diabetic groups relative to untreated counterparts. Con: nondiabetic control, CCAE-Con: nondiabetic control treated with CCAE, NIA/STZ: early-stage diabetic group, CCAE-NIA/STZ: the early-stage diabetic group treated with CCAE, STZ: late-stage diabetic group, CCAE-STZ: the late-stage diabetic group treated with CCAE. *, p < 0.05; †, p = 0.001. #, p < 0.05 and ##, p < 0.01 show significant differences between the diabetic group (STZ or NIA/STZ, respectively) versus Con

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