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International Journal of Phytomedicine and Phytotherapy

Table 4 Summary of the study items and the results

From: Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

Measured parameters ET2D LT2D
Before CCAE After CCAE Before CCAE After CCAE
CCAE effect on short-term blood sugar (IPGTT) ↑↑
Extent of impaired glucose tolerance (AUC in IPGTT) NA ↑↑ NA
Measured parameters on day 28
 FBS ↑↑ ↓↓
 HbA1c –e
 Hepatic PCC
 G6Pase mRNA
 PEPCK mRNA
 CPT1 ↑↑ ↓↓
 Hepatic TG
 Blood TG
 Body weight
 C-peptide ↓↓
 SREBP-1c mRNA ↓↓
 ACC mRNA ↓↓
 FAS mRNA
 PPARα mRNA ↑↑