Skip to main content

International Journal of Phytomedicine and Phytotherapy

Table 4 Summary of the study items and the results

From: Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

Measured parameters

ET2D

LT2D

Before CCAE

After CCAE

Before CCAE

After CCAE

CCAE effect on short-term blood sugar (IPGTT)

↑

↓

↑↑

–

Extent of impaired glucose tolerance (AUC in IPGTT)

↑

NA

↑↑

NA

Measured parameters on day 28

 FBS

↑

↓

↑↑

↓↓

 HbA1c

–

–e

↑

–

 Hepatic PCC

–

↓

–

↓

 G6Pase mRNA

↑

↓

–

–

 PEPCK mRNA

–

–

↑

–

 CPT1

↑

–

↑↑

↓↓

 Hepatic TG

↑

↓

↑

↓

 Blood TG

↑

↓

–

↓

 Body weight

↑

–

↓

–

 C-peptide

↓

–

↓↓

–

 SREBP-1c mRNA

↓

–

↓↓

–

 ACC mRNA

↓

–

↓↓

–

 FAS mRNA

↓

–

↓

–

 PPARα mRNA

↓

↑

↓

↑↑