Plate 1

Photomicrograph Sections of the Hepatocytes of Streptozotocin induced Diabetic Rats fed on a High Fat Diet. A = Glibenclamide (10 mg/kg): Section reveals distinct centriole (long arrow) in the hepatocytes and well fenestrated sinusoids with mild mononuclear cells (short arrow). B = Negative control (untreated): Reveals centriole (long arrow) with noticeable inflammatory cells surrounding it (medium arrow). The hepatocytes shows mild stenosis and fatty changes (short arrow). C = S. jamaicensis extract (30 mg/kg): Features reveal visible centriole (long arrow) with well fenestrated sinusoids. The nucleus appears pyknotic with mild fatty changes (short arrow). D = S. jamaicensis extract (50 mg/kg): Shows visible centriole (long arrow) with well fenestrated sinusoids and nucleus that appears pyknotic with stenosis (short arrow). E = S. jamaicensis extract (100 mg/kg): reveals centriole (long arrow) with pyknotic nucleus and hepatocytes showing mild stenosis and fatty changes (short arrow). [H & E staining; × 40 magnification]