International Journal of Phytomedicine and Phytotherapy
Table 3 ADMET distribution profiles of the six bioactive compounds
Bioactive compounds | G1 Absorption | BBB Permeability | P-gp Substrate | CYP1A2 Inhibitor | CYP2C19 Inhibitor | CYP2C9 Inhibitor | CYP2D6 Inhibitor | CYP3A4 Inhibitor |
|---|---|---|---|---|---|---|---|---|
Caffeic acid | High | No | No | No | No | No | No | No |
Gallic acid | High | No | No | No | No | No | No | Yes |
Metformin | High | No | No | No | No | No | No | No |
Quercetin | High | No | No | Yes | No | No | Yes | Yes |
Rutin | Low | No | Yes | No | No | No | No | No |
Chlorogenic acid | Low | No | No | No | No | No | No | No |
Kaempferol | High | No | No | Yes | No | No | Yes | Yes |