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International Journal of Phytomedicine and Phytotherapy

Table 3 ADMET distribution profiles of the six bioactive compounds

From: Molecular interaction of bioactive compounds from Senecio biafrae leaf with α-amylase and α-glucosidase receptors

Bioactive compounds G1 Absorption BBB Permeability P-gp Substrate CYP1A2
Inhibitor
CYP2C19
Inhibitor
CYP2C9
Inhibitor
CYP2D6
Inhibitor
CYP3A4
Inhibitor
Caffeic acid High No No No No No No No
Gallic acid High No No No No No No Yes
Metformin High No No No No No No No
Quercetin High No No Yes No No Yes Yes
Rutin Low No Yes No No No No No
Chlorogenic acid Low No No No No No No No
Kaempferol High No No Yes No No Yes Yes